大鼠交感神经切除术后唾液的变性分泌
Degeneration secretion of saliva in the rat following sympathectomy.
作者信息
Delfs U, Emmelin N
出版信息
J Physiol. 1974 Jun;239(3):623-30. doi: 10.1113/jphysiol.1974.sp010585.
Abstract
- After previous extirpation of the superior cervical ganglion saliva was found to flow from the cannulated submaxillary duct of rats under chloralose anaesthesia. The secretion started 13-14.5 hr after sympathectomy, increased gradually in rate and then slowed down and ceased, lasting for about 12 hr.2. Injection of alpha- or beta-adrenoreceptor blocking drugs reduced the flow and a combination of both types of drugs abolished it. It is concluded that the secretion was caused by noradrenaline released from the degenerating nerves, and that the phenomenon is an example of the degeneration activity described in other preparations as an effect of section of post-ganglionic autonomic nerves.3. A similar, but less pronounced, secretion was found in the parotid gland of the rat.
摘要
在先前切除颈上神经节后，发现在氯醛糖麻醉下大鼠的下颌下腺导管插管中有唾液流出。分泌在交感神经切除后13 - 14.5小时开始，速率逐渐增加，然后减慢并停止，持续约12小时。
注射α或β肾上腺素能受体阻断药物可减少唾液分泌，两种药物联合使用则可消除分泌。得出的结论是，分泌是由退化神经释放的去甲肾上腺素引起的，并且该现象是在其他制剂中所描述的节后自主神经切断效应的退化活动的一个例子。
在大鼠的腮腺中发现了类似但不太明显的分泌现象。
相似文献
1
Degeneration secretion of saliva in the rat following sympathectomy.大鼠交感神经切除术后唾液的变性分泌
J Physiol. 1974 Jun;239(3):623-30. doi: 10.1113/jphysiol.1974.sp010585.
2
Vasoactive intestinal peptide evoked secretion of fluid and protein from rat salivary glands and the development of supersensitivity.血管活性肠肽可诱发大鼠唾液腺分泌液体和蛋白质，并产生超敏反应。
Acta Physiol Scand. 1983;119(2):169-75. doi: 10.1111/j.1748-1716.1983.tb07322.x.
3
The effects of 5-hydroxydopamine on salivary flow rates and protein secretion by the submandibular and parotid glands of rats.5-羟多巴胺对大鼠下颌下腺和腮腺唾液流速及蛋白质分泌的影响。
Exp Physiol. 1996 Jul;81(4):645-53. doi: 10.1113/expphysiol.1996.sp003965.
4
Time course of degeneration of short and long postganglionic sympathetic nerve fibres and effect of pentobarbitone and colchicine on degeneration.短和长节后交感神经纤维变性的时间进程以及戊巴比妥和秋水仙碱对变性的影响
Br J Pharmacol. 1978 Apr;62(4):553-61. doi: 10.1111/j.1476-5381.1978.tb07761.x.
5
Effect of clonidine on secretion of fluid and ions by the parotid and submandibular glands of the rat.可乐定对大鼠腮腺和颌下腺液体及离子分泌的影响。
Arch Oral Biol. 1987;32(1):27-33. doi: 10.1016/0003-9969(87)90150-6.
6
Parotid degeneration secretion of amylase in vitro in the rat following sympathectomy.大鼠交感神经切除术后腮腺变性淀粉酶的体外分泌
Q J Exp Physiol. 1982 Jan;67(1):7-15. doi: 10.1113/expphysiol.1982.sp002626.
7
Structural changes associated with parotid "degeneration secretion" after post-ganglionic sympathectomy in rats.大鼠节后交感神经切除术后腮腺“变性分泌”相关的结构变化
Cell Tissue Res. 1975 Sep 16;162(1):1-12. doi: 10.1007/BF00223257.
8
Effect of adrenergic agents on salivary composition.肾上腺素能药物对唾液成分的影响。
J Dent Res. 1975 Jun;54 Spec No B:B27-33. doi: 10.1177/00220345750540022001.
9
Secretion of IgA by rat parotid and submandibular cells in response to autonomimetic stimulation in vitro.体外自主神经模拟刺激下大鼠腮腺和颌下腺细胞IgA的分泌
Int Immunopharmacol. 2004 Aug;4(8):1005-14. doi: 10.1016/j.intimp.2004.03.013.
10
Calcium levels in rat submandibular gland and saliva after sympathetic nerve stimulation in the presence of alpha, beta 1 and beta 2-adrenergic antagonists.
Arch Oral Biol. 1986;31(6):383-6. doi: 10.1016/0003-9969(86)90161-5.
引用本文的文献
1
Clinical implications of aberrant neurovascular structures coursing through the submandibular gland.穿行于下颌下腺的异常神经血管结构的临床意义。
PeerJ. 2019 Oct 2;7:e7823. doi: 10.7717/peerj.7823. eCollection 2019.
2
Effects of continuous light on rat parotid gland structure and reactivity.持续光照对大鼠腮腺结构及反应性的影响。
Anat Embryol (Berl). 1989;179(5):497-501. doi: 10.1007/BF00319593.
3
Proceedings: Control of amylase secretion in the parotid gland.论文集：腮腺中淀粉酶分泌的控制
J Physiol. 1975 Aug;250(1):1P-2P.
4
Structural changes associated with parotid "degeneration secretion" after post-ganglionic sympathectomy in rats.大鼠节后交感神经切除术后腮腺“变性分泌”相关的结构变化
Cell Tissue Res. 1975 Sep 16;162(1):1-12. doi: 10.1007/BF00223257.
5
Secretory effects of 6-hydroxydopamine in normal and denervated submaxillary glands of the rat.6-羟基多巴胺对大鼠正常及去神经支配下颌下腺的分泌作用
Naunyn Schmiedebergs Arch Pharmacol. 1977 Jul;298(3):245-53. doi: 10.1007/BF00500895.
6
The role of cyclic 3',5'-adenosine monophosphate (cyclic AMP) in the ability of sympathetic nerve stimulation to enhance growth and secretion in rat salivary glands in vivo.环磷腺苷（cAMP）在交感神经刺激增强大鼠唾液腺体内生长和分泌能力中的作用。
J Physiol. 1976 Jul;259(1):47-61. doi: 10.1113/jphysiol.1976.sp011454.
本文引用的文献
1
THE ANTIARRHYTHMIC ACTIONS OF BETA ADRENERGIC BLOCKING AGENTS.β肾上腺素能阻滞剂的抗心律失常作用
J Pharmacol Exp Ther. 1965 Feb;147:194-204.
2
EFFECTS OF BRETYLIUM, RESERPINE, GUANETHIDINE AND SYMPATHETIC DENERVATION ON THE NORADRENALINE CONTENT OF THE RAT SUBMAXILLARY GLAND.溴苄铵、利血平、胍乙啶及交感神经切除对大鼠颌下腺去甲肾上腺素含量的影响
Acta Physiol Scand. 1963 Sep-Oct;59:34-42. doi: 10.1111/j.1748-1716.1963.tb02720.x.
3
Accumulation of epinephrine and norepinephrine by some rat tissues.某些大鼠组织对肾上腺素和去甲肾上腺素的蓄积
J Pharmacol Exp Ther. 1961 Nov;134:154-9.
4
Submaxillary and sublingual secretion in cats during degeneration of post-ganglionic parasympathetic fibres.节后副交感神经纤维变性过程中猫的颌下腺和舌下腺分泌
J Physiol. 1962 Jul;162(2):270-81. doi: 10.1113/jphysiol.1962.sp006931.
5
The short-term effects of sympathetic ganglionectomy on the cat's salivary secretion.交感神经节切除术对猫唾液分泌的短期影响。
J Physiol. 1962 Jul;162(2):282-8. doi: 10.1113/jphysiol.1962.sp006932.
6
A paroxysmal secretion of saliva following parasympathetic denervation of the parotid gland.腮腺副交感神经去神经支配后唾液的阵发性分泌。
J Physiol. 1958 Oct 31;143(3):506-14. doi: 10.1113/jphysiol.1958.sp006074.
7
Autonomic pathways involved in a sympathetic-like action of pilocarpine on salivary composition.
Proc Soc Exp Biol Med. 1966 Jan;121(1):96-100. doi: 10.3181/00379727-121-30707.
8
9
Adrenergic innervation of the salivary glands in the rat.大鼠唾液腺的肾上腺素能神经支配。
Z Zellforsch Mikrosk Anat. 1965 Oct 12;68(2):183-9. doi: 10.1007/BF00342427.
10
Histochemical demonstration of noradrenaline in rat salivary glands.大鼠唾液腺中去甲肾上腺素的组织化学显示
Jpn J Pharmacol. 1965 Dec;15(4):369-77. doi: 10.1254/jjp.15.369.
Zotero 插件