小鼠锂中毒的昼夜节律。

Circadian rhythm of lithium toxicity in mice.

作者信息

Hawkins R, Kripke D F, Janowsky D S

出版信息

Psychopharmacology (Berl). 1978 Jan 31;56(1):113-4. doi: 10.1007/BF00571418.

Abstract

The existence of cyclical (circadian) variations in lithium toxicity in mice was determined. Mice, standardized to a light-dark cycle, were injected with lithium chloride (940 mg/kg) at one of six times (20:00, 24:00, 4:00, 8:00, 12:00, and 16:00) and subsequently observed for mortality over 28 h. A significant (P less than 0.01) time-of-day effect was found for lithium-induced lethality, with highest lethality following injection at 12:00.

摘要

已确定小鼠锂中毒存在周期性（昼夜节律）变化。将小鼠按照明暗周期进行标准化处理，在六个时间点之一（20:00、24:00、4:00、8:00、12:00和16:00）注射氯化锂（940毫克/千克），随后观察28小时内的死亡率。发现锂诱导的致死率存在显著的（P小于0.01）一天中的时间效应，12:00注射后致死率最高。