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Δ9-四氢大麻酚:对小鼠、大鼠和松鼠猴的抗攻击作用。

delta9-tetrahydrocannabinol: antiaggressive effects in mice, rats, and squirrel monkeys.

作者信息

Miczek K A

出版信息

Science. 1978 Mar 31;199(4336):1459-61. doi: 10.1126/science.415367.

DOI:10.1126/science.415367
PMID:415367
Abstract

delta9-Tetrahydrocannabinol, the most active constituent of marihuana, decreased species-specific attack behavior in mice, rats, and squirrel monkeys at doses (0.25 to 2.0 milligram per kilogram of body weight) that have no effects on other elements of the behavioral repertoire. Aggressive behavior was engendered in all three species by confronting a resident animal with an intruder conspecific. The present results contrast with the widely held belief that marihuana increases aggressive behavior.

摘要

Δ⁹-四氢大麻酚是大麻中最具活性的成分,在剂量为0.25至2.0毫克/千克体重时,可降低小鼠、大鼠和松鼠猴的种属特异性攻击行为,而此剂量对行为模式的其他方面并无影响。通过将一只陌生同种动物与一只居主导地位的动物对峙,在这三个物种中均可引发攻击行为。目前的结果与人们普遍认为大麻会增加攻击行为的观点形成了对比。

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