通过口服金化合物SK & F 36914在滑膜中产生的金质体。
Aurosomes produced in the synovial membrane by the oral administration of a gold compound SK & F 36914.
作者信息
Thomas I, Ghadially F N
出版信息
Virchows Arch B Cell Pathol. 1977 Dec 30;26(2):105-9. doi: 10.1007/BF02889539.
PMID:415423
Abstract
Chlorotriethylphosphine gold (SK & F 36914) administered orally to rabbits produced aurosomes in the synovial membrane. These aurosomes were similar to aurosomes produced by parenteral or intra-articular injections of soluble gold salts such as sodium aurothiomalate and aurothioglucose. This study shows, (1) that an orally administered gold compound is capable of producing gold deposits in the synovial membrane, and (2) that such compounds may have a future in the treatment of rheumatoid arthritis.
摘要
给兔子口服氯三乙膦金（SK&F 36914）可在滑膜中产生金体。这些金体类似于通过肠胃外或关节内注射硫代苹果酸钠金和硫代葡萄糖金等可溶性金盐所产生的金体。本研究表明，（1）口服金化合物能够在滑膜中产生金沉积，（2）此类化合物在类风湿性关节炎的治疗中可能具有前景。
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Aurosomes produced in the synovial membrane by the oral administration of a gold compound SK & F 36914.通过口服金化合物SK & F 36914在滑膜中产生的金质体。
Virchows Arch B Cell Pathol. 1977 Dec 30;26(2):105-9. doi: 10.1007/BF02889539.
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引用本文的文献
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Comparative pharmacokinetics of triethylphosphine gold (auranofin) and gold sodium thiomalate (GST).三乙膦金（金诺芬）与硫代苹果酸金钠（GST）的比较药代动力学
Clin Rheumatol. 1984 Mar;3 Suppl 1:17-24. doi: 10.1007/BF03342618.
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Clinical pharmacokinetics of oral and injectable gold compounds.口服和注射用金化合物的临床药代动力学
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