Horowski R, Wendt H, Gräf K J
Acta Endocrinol (Copenh). 1978 Feb;87(2):234-40. doi: 10.1530/acta.0.0870234.
Lisuride, a new semisynthetic ergot derivative, effectively decreased the TRH-induced hyperprolactinaemia in healthy female volunteers at a dose of 300 microgram given orally. Basal prolactin levels were suppressed after a single dose of 100 and 200 microgram lisuride. This effect was still present 6 h after administration. Two hundred microgram lisuride also decreased the high serum prolactin levels produced by im injection of 50 mg sulpiride, and conversely, sulpiride injection abolished the prolactin lowering effect of lisuride. These results demonstrate that in man too lisuride is a very potent prolactin-lowering agent. In addition, the data support the hypothesis of a predominant role of dopaminergic mechanisms in the regulation of prolactin secretion.
利舒脲，一种新型半合成麦角衍生物，在健康女性志愿者中口服300微克剂量时可有效降低促甲状腺激素释放激素诱导的高催乳素血症。单次服用100微克和200微克利舒脲后，基础催乳素水平受到抑制。给药6小时后这种作用仍然存在。200微克利舒脲也降低了肌肉注射50毫克舒必利所产生的高血清催乳素水平，相反，注射舒必利则消除了利舒脲降低催乳素的作用。这些结果表明，在人体中利舒脲也是一种非常有效的催乳素降低剂。此外，这些数据支持多巴胺能机制在催乳素分泌调节中起主要作用的假说。
