Durand M, Chauvergne J, Hoerni-Simon G, Meugé C, De Mascarel A, Richaud P, Brunet R, Hoerni B, Lagarde C
Acta Haematol. 1978;59(2):80-7. doi: 10.1159/000207749.
Two types of chemotherapy have been compared in a randomized trial to treat non-Hodgkin malignant lymphomas. 66 patients were included in this study, but only 40 were evaluable after a histologic review of all cases. Treatment were an association of cyclophosphamide, vincristine, prednisone and doxorubicine or VM 26. Patients received only one induction chemotherapy course during 15--20 days. Results were evaluated immediately at the end of the course. Side-effects were mild. Efficacy was about the same with the two protocols: 35 patients out of 40 experienced a remission of more than 50% (among them 8 experienced a complete remission). These results are better than previous one obtained with cyclophosphamide, vincristine and prednisone only. It is concluded that this type of treatment is well tolerated, quickly efficient and useful before treating patients with radiotherapy or long-term chemotherapy.
在一项随机试验中对两种化疗方法进行了比较，以治疗非霍奇金恶性淋巴瘤。本研究纳入了66例患者，但在对所有病例进行组织学检查后，仅有40例可进行评估。治疗方案为环磷酰胺、长春新碱、泼尼松和阿霉素联合使用或VM 26。患者在15至20天内仅接受一个诱导化疗疗程。疗程结束后立即评估结果。副作用轻微。两种方案的疗效大致相同：40例患者中有35例缓解率超过50%（其中8例完全缓解）。这些结果优于之前仅使用环磷酰胺、长春新碱和泼尼松所获得的结果。得出的结论是，这种治疗方法耐受性良好、起效迅速，在对患者进行放疗或长期化疗之前很有用。
