一种新型β-肾上腺素能受体阻断化合物托拉洛尔对人体血液动力学和心肌功能的影响。
The effects of a new beta-adrenoceptor blocking compound, tolamolol, on haemo-dynamics and myocardial function in man.
作者信息
Hillis W S, Hutton I, Lawrie T D, Lorimer A R, Reid J M
出版信息
Br J Pharmacol. 1974 May;51(1):15-9. doi: 10.1111/j.1476-5381.1974.tb09626.x.
1 The effects of tolamolol on haemodynamics and myocardial contractility were investigated in two groups of six patients undergoing diagnostic cardiac catheterization.2 The intravenous administration of tolamolol (0.15 mg/kg) produced a significant fall in heart rate from a control value (87 +/- 7 to 62 +/- 3 beats/min) 5 min after administration and a concomitant fall in cardiac output from 4.7 +/- 0.9 to 3.5 +/- 0.8 litres/minute. There was no significant change in systemic blood pressure, pulmonary artery blood pressure or stroke volume.3 There was no change in left ventricular end diastolic pressure after tolamolol. There was a fall in the maximum rate of rise of the left ventricular pressure (LV dp/dt(max)) and the derived index of the left ventricular contractile state (V(max)).4 These results suggest that tolamolol has a predominantly negative chronotropic but also a lesser negative inotropic action on the heart.
在两组各六名接受诊断性心导管插入术的患者中，研究了托拉洛尔对血流动力学和心肌收缩力的影响。
静脉注射托拉洛尔（0.15毫克/千克）后5分钟，心率从对照值（87±7降至62±3次/分钟）显著下降，心输出量也随之从4.7±0.9降至3.5±0.8升/分钟。全身血压、肺动脉血压或每搏量无显著变化。
托拉洛尔注射后左心室舒张末期压力无变化。左心室压力最大上升速率（LV dp/dt(max)）和左心室收缩状态衍生指数（V(max)）下降。
这些结果表明，托拉洛尔对心脏主要有负性变时作用，但也有较小的负性变力作用。
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