短裸甲藻毒素对豚鼠回肠平滑肌标本的作用。
Effects of Gymnodinium breve toxin on the smooth muscle preparation of guinea-pig ileum.
作者信息
Grunfeld Y, Spiegelstein M Y
出版信息
Br J Pharmacol. 1974 May;51(1):67-72. doi: 10.1111/j.1476-5381.1974.tb09633.x.
1 The effects of Gymnodinium breve neurotoxin (GT) on smooth muscles were studied using the guinea-pig isolated ileum.2 The toxin caused strong spasmogenic effects at 1-4 mug/ml, characterized by prolonged tonic contraction with superimposed pronounced pendular movements. Tachyphylaxis was observed upon administration of successive doses.3 Atropine blocked the contractile response elicited by GT, whereas mepyramine and hexamethonium failed to do so. These findings tentatively suggested a cholinergic involvement at a post-ganglionic site of action.4 In the presence of tetrodotoxin the effects of GT were abolished, excluding direct action of the toxin on the smooth muscle.5 It is concluded that GT exerts its spasmogenic effects through stimulation of the post-ganglionic cholinergic nerve fibres.
使用豚鼠离体回肠研究了短裸甲藻神经毒素（GT）对平滑肌的作用。
该毒素在1 - 4微克/毫升时引起强烈的致痉挛作用，其特征为伴有明显摆动运动的持续性强直性收缩延长。连续给药时观察到快速耐受性。
阿托品阻断了GT引起的收缩反应，而美吡拉敏和六甲铵则不能。这些发现初步提示在神经节后作用部位有胆碱能参与。
在存在河豚毒素的情况下，GT的作用被消除，排除了毒素对平滑肌的直接作用。
得出的结论是，GT通过刺激神经节后胆碱能神经纤维发挥其致痉挛作用。
Zotero 插件