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Pharmacokinetic studies on the selective beta1-receptor antagonist metoprolol in man.

作者信息

Regårdh C G, Borg K O, Johansson R, Johnsson G, Palmer L

出版信息

J Pharmacokinet Biopharm. 1974 Aug;2(4):347-64. doi: 10.1007/BF01061407.

DOI:10.1007/BF01061407
PMID:4155762
Abstract
摘要

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Pharmacokinetic studies on the selective beta1-receptor antagonist metoprolol in man.人用选择性β1受体拮抗剂美托洛尔的药代动力学研究。
J Pharmacokinet Biopharm. 1974 Aug;2(4):347-64. doi: 10.1007/BF01061407.
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Combined pharmacokinetic and pharmacodynammc studies in man of the adrenergic beta1-receptor antagonist metoprolol.肾上腺素能β1受体拮抗剂美托洛尔在人体中的药代动力学和药效学联合研究。
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Direct proportionality of urinary excretion rate and serum level of tetracycline in human subjects.人体受试者中四环素的尿排泄率与血清水平的直接比例关系。
Nature. 1963 May 4;198:450-3. doi: 10.1038/198450a0.
2
Per cent absorbed time plots derived from blood level and/or urinary excretion data.根据血药浓度和/或尿排泄数据得出的吸收百分比-时间曲线图。
J Pharm Sci. 1963 Jun;52:610-1. doi: 10.1002/jps.2600520629.
3
New method for calculating the intrinsic absorption rate of drugs.计算药物内在吸收速率的新方法。
细胞旁路转运在米诺地尔肠道吸收及生物药剂学特征中的作用
Pharmaceutics. 2022 Jun 27;14(7):1360. doi: 10.3390/pharmaceutics14071360.
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Clinical Pharmacokinetics of Metoprolol: A Systematic Review.美托洛尔的临床药代动力学:系统评价。
Clin Pharmacokinet. 2022 Aug;61(8):1095-1114. doi: 10.1007/s40262-022-01145-y. Epub 2022 Jun 28.
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Development of Extended-Release Mini-Tablets Containing Metoprolol Supported by Design of Experiments and Physiologically Based Biopharmaceutics Modeling.基于实验设计和生理药剂学模型的美托洛尔缓释微型片的研发
Pharmaceutics. 2022 Apr 19;14(5):892. doi: 10.3390/pharmaceutics14050892.
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Extracorporeal treatment for poisoning to beta-adrenergic antagonists: systematic review and recommendations from the EXTRIP workgroup.体外治疗β-肾上腺素能拮抗剂中毒:EXTRIP 工作组的系统评价和建议。
Crit Care. 2021 Jun 10;25(1):201. doi: 10.1186/s13054-021-03585-7.
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Day-to-day progression of vital-sign circadian rhythms in the intensive care unit.重症监护病房生命体征昼夜节律的日常进展。
Crit Care. 2021 Apr 22;25(1):156. doi: 10.1186/s13054-021-03574-w.
8
Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions.美托洛尔对映体和α-羟基美托洛尔的基于生理的药代动力学建模以描述CYP2D6药物-基因相互作用
Pharmaceutics. 2020 Dec 11;12(12):1200. doi: 10.3390/pharmaceutics12121200.
9
Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions.利用微粒体分配预测组织-血浆分配系数:纳入基于生理的药代动力学模型和稳态分布容积预测。
Drug Metab Dispos. 2019 Oct;47(10):1050-1060. doi: 10.1124/dmd.119.087973. Epub 2019 Jul 19.
10
Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug.参与美托洛尔代谢的细胞色素P450酶以及美托洛尔作为CYP2D6表型分析探针药物的应用。
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Influence of first-pass effect on availability of drugs on oral administration.首过效应对口服给药时药物可利用度的影响。
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Pharmacokinetic model for chlordiazepoxide--HCl in the dog.狗体内氯氮䓬盐酸盐的药代动力学模型。
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Assessment of pharmacokinetic constants from postinfusion blood curves obtained after I.V. infusion.通过静脉输注后获得的输注后血药浓度曲线评估药代动力学常数。
J Pharm Sci. 1970 Jan;59(1):53-5. doi: 10.1002/jps.2600590107.
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Influence of route of administration on drug availability.给药途径对药物可利用性的影响。
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Prediction of systemic availability from plasma-level data after oral drug administration.
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Pharmacological studies of two new cardioselective adrenergic beta-receptor antagonists.两种新型心脏选择性肾上腺素能β受体拮抗剂的药理学研究
Life Sci I. 1973 Feb 1;12(3):107-19. doi: 10.1016/0024-3205(73)90368-8.