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1
The effects of three beta-adrenoceptor blocking drugs on isolated preparations of skeletal and cardiac muscle.三种β-肾上腺素能受体阻断药物对骨骼肌和心肌离体标本的作用。
Br J Pharmacol. 1974 Oct;52(2):275-81. doi: 10.1111/j.1476-5381.1974.tb09710.x.
2
The actions of a new beta-adrenoceptor blocking drug, ICI 66082, on the rabbit papillary muscle and on the dog heart.一种新型β-肾上腺素能受体阻断药物ICI 66082对兔乳头肌和犬心脏的作用。
Br J Pharmacol. 1974 Jun;51(2):169-77. doi: 10.1111/j.1476-5381.1974.tb09644.x.
3
Influence of intrinsic sympathomimetic activity and cardioselectivity on beta adrenoceptor blockade.内在拟交感活性和心脏选择性对β肾上腺素能受体阻滞的影响。
Clin Pharmacol Ther. 1977 May;21(5):556-66. doi: 10.1002/cpt1977215556.
4
Comparison of beta-adrenergic blocking activities of propranolol, isopropylmethoxamine, sotalol, practolol, alprenolol, pindolol, oxprenolol and D-32 in the atria and trachea of the guinea-pig.普萘洛尔、异丙甲胺、索他洛尔、普拉洛尔、阿普洛尔、吲哚洛尔、氧烯洛尔和D-32对豚鼠心房和气管的β-肾上腺素能阻断活性比较。
Arzneimittelforschung. 1974 Sep;24(9):1275-7.
5
Comparative partial agonist activity of -adrenoceptor antagonists.β-肾上腺素能受体拮抗剂的比较性部分激动剂活性。
Br J Pharmacol. 1972 Jun;45(2):382-4. doi: 10.1111/j.1476-5381.1972.tb08094.x.
6
Beta-adrenoceptor blocking agents and responses to adrenaline and 5-hydroxytryptamine in rat isolated stomach and uterus.β-肾上腺素受体阻断剂与大鼠离体胃和子宫对肾上腺素及5-羟色胺的反应
Br J Pharmacol. 1974 Oct;52(2):283-7. doi: 10.1111/j.1476-5381.1974.tb09711.x.
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A study of some beta-adrenoceptor blocking agents on skeletal muscle.某些β-肾上腺素能受体阻滞剂对骨骼肌作用的研究。
Arzneimittelforschung. 1975 Jan;25(1):52-5.
8
Beta-adrenergic receptor blocking drugs in spontaneous hypertension.β-肾上腺素能受体阻断药与自发性高血压
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9
Influence of the beta-adrenergic antagonists propranolol, practolol and oxprenolol on the proliferation of rat jejunal crypt cells.β-肾上腺素能拮抗剂普萘洛尔、普拉洛尔和氧烯洛尔对大鼠空肠隐窝细胞增殖的影响。
Cell Tissue Kinet. 1986 Jan;19(1):109-20. doi: 10.1111/j.1365-2184.1986.tb00719.x.
10
The beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat.烯丙洛尔、氧烯洛尔和吲哚洛尔对β1和β2肾上腺素能受体的激动作用：大鼠离体右心房和子宫的研究
Br J Pharmacol. 1986 Apr;87(4):657-64. doi: 10.1111/j.1476-5381.1986.tb14582.x.

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Pathomechanisms and Clinical Implications of Myasthenic Syndromes Exacerbated and Induced by Medical Treatments.药物治疗诱发和加重的肌无力综合征的发病机制及临床意义
Front Mol Neurosci. 2020 Aug 14;13:156. doi: 10.3389/fnmol.2020.00156. eCollection 2020.
2
Inhibition by propranolol of the contractile response of the rat diaphragm to tetanic field stimulation in vitro.普萘洛尔对大鼠膈肌体外强直场刺激收缩反应的抑制作用。
Br J Pharmacol. 1983 Dec;80(4):613-8. doi: 10.1111/j.1476-5381.1983.tb10050.x.
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The beta 1- and beta 2-adrenoceptor affinity and beta 1-blocking potency of S- and R-metoprolol.S-美托洛尔和R-美托洛尔的β1及β2肾上腺素能受体亲和力与β1阻断效能
Br J Pharmacol. 1990 Mar;99(3):592-6. doi: 10.1111/j.1476-5381.1990.tb12974.x.

本文引用的文献

1
THE USE OF SYMPATHETIC BETA-RECEPTOR BLOCKING AGENTS IN THE INVESTIGATION OF REFLEX CHANGES IN HEART RATE.交感神经β受体阻滞剂在心率反射性变化研究中的应用
Br J Pharmacol Chemother. 1965 Jun;24(3):781-8. doi: 10.1111/j.1476-5381.1965.tb01634.x.
2
PHYSICAL FACTORS IN THE ANALYSIS OF THE ACTIONS OF DRUGS ON MYOCARDIAL CONTRACTILITY.分析药物对心肌收缩力作用中的物理因素
Pharmacol Rev. 1963 Sep;15:531-99.
3
Energy production in cardiac isotonic contractions.心脏等张收缩中的能量产生。
J Gen Physiol. 1970 Dec;56(6):732-50. doi: 10.1085/jgp.56.6.732.
4
Perspectives in adrenergic beta-receptor blockade.肾上腺素能β受体阻滞剂的展望
Clin Pharmacol Ther. 1969 May-Jun;10(3):292-306. doi: 10.1002/cpt1969103292.
5
Action of propranolol on the dog heart.普萘洛尔对犬心脏的作用。
Cardiovasc Res. 1973 Nov;7(6):729-39. doi: 10.1093/cvr/7.6.729.
6
Comparative partial agonist activity of -adrenoceptor antagonists.β-肾上腺素能受体拮抗剂的比较性部分激动剂活性。
Br J Pharmacol. 1972 Jun;45(2):382-4. doi: 10.1111/j.1476-5381.1972.tb08094.x.
7
Effects of -adrenoreceptor blocking drugs on isolated skeletal and cardiac muscle.β-肾上腺素能阻断药物对离体骨骼肌和心肌的作用。
Br J Pharmacol. 1971 Oct;43(2):453P-454P.
8
Effects of oxprenolol on cardiac contractile force, heart rate and coronary circulation.氧烯洛尔对心脏收缩力、心率及冠脉循环的影响。
Postgrad Med J. 1970 Nov:Suppl:15-21.
9
Clinical pharmacology of beta-receptor-blocking drugs.β受体阻滞剂的临床药理学
Clin Pharmacol Ther. 1969 Nov-Dec;10(6):765-99.
10
A comparison of the local anaesthetic-, "quinidine-like"- and adrenergic beta-blocking-activities of five beta-receptor antagonists.五种β受体拮抗剂的局部麻醉、“奎尼丁样”及肾上腺素能β受体阻断活性比较
J Pharm Pharmacol. 1970 Apr;22(4):284-90. doi: 10.1111/j.2042-7158.1970.tb08520.x.

三种β-肾上腺素能受体阻断药物对骨骼肌和心肌离体标本的作用。

The effects of three beta-adrenoceptor blocking drugs on isolated preparations of skeletal and cardiac muscle.

作者信息

Harry J D, Linden R J, Snow H M

出版信息

Br J Pharmacol. 1974 Oct;52(2):275-81. doi: 10.1111/j.1476-5381.1974.tb09710.x.

DOI:10.1111/j.1476-5381.1974.tb09710.x
PMID:4155991
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776866/
Abstract

1 The effects of propranolol, oxprenolol and practolol on the isometric twitch responses to electrical stimulation of isolated diaphragm muscles from the rat and of isolated papillary muscles from the rabbit are described.2 Depression of the twitch responses of the diaphragm muscle was produced by propranolol (20 mug/ml), by oxprenolol (100 mug/ml) and by practolol (500 mug/ml).3 Depression of the twitch responses of the papillary muscles was produced by propranolol (20 mug/ml) by oxprenolol (100 mug/ml) and by practolol (200 mug/ml).4 No increase of twitch tension was produced by oxprenolol or practolol on either tissue.5 It is concluded that propranolol, oxprenolol and practolol produce negative inotropic actions on isolated cardiac muscle by a mechanism unrelated to blockade of beta-adrenoceptors and which occurs at doses which are well in excess of those doses required to produce beta-blockade.

摘要

  1. 描述了普萘洛尔、氧烯洛尔和普拉洛尔对大鼠离体膈肌及兔离体乳头肌电刺激引起的等长收缩反应的影响。

  2. 普萘洛尔（20微克/毫升）、氧烯洛尔（100微克/毫升）和普拉洛尔（500微克/毫升）可使膈肌的收缩反应减弱。

  3. 普萘洛尔（20微克/毫升）、氧烯洛尔（100微克/毫升）和普拉洛尔（200微克/毫升）可使乳头肌的收缩反应减弱。

  4. 氧烯洛尔或普拉洛尔对两种组织均未引起收缩张力增加。

  5. 得出结论：普萘洛尔、氧烯洛尔和普拉洛尔对离体心肌产生负性肌力作用，其机制与β-肾上腺素受体阻断无关，且发生在远超过产生β-阻断所需剂量的剂量水平。