哺乳动物大脑中的腐胺分解代谢
Putrescine catabolism in mammalian brain.
作者信息
Seiler N, Al-Therib M J
出版信息
Biochem J. 1974 Oct;144(1):29-35. doi: 10.1042/bj1440029.
Abstract
In contrast with putrescine (1,4-diaminobutane), which is a substrate of diamine oxidase, monoacetylputrescine is oxidatively deaminated both in vitro and in vivo by monoamine oxidase. The product of this reaction is N-acetyl-gamma-aminobutyrate. The existence of a degradative pathway in mammalian brain for putrescine is shown, which comprises acetylation of putrescine, oxidative deamination of monoacetylputrescine to N-acetyl-gamma-aminobutyrate, transformation of N-acetyl-gamma-aminobutyrate to gamma-aminobutyrate and degradation of gamma-aminobutyrate to CO(2) via the tricarboxylic acid cycle.
摘要
与作为二胺氧化酶底物的腐胺（1,4 - 二氨基丁烷）不同，单乙酰腐胺在体外和体内均可被单胺氧化酶氧化脱氨。该反应的产物是N - 乙酰 - γ - 氨基丁酸。结果表明，哺乳动物大脑中存在一条腐胺降解途径，该途径包括腐胺的乙酰化、单乙酰腐胺氧化脱氨生成N - 乙酰 - γ - 氨基丁酸、N - 乙酰 - γ - 氨基丁酸转化为γ - 氨基丁酸以及γ - 氨基丁酸通过三羧酸循环降解为CO₂ 。
相似文献
1
Putrescine catabolism in mammalian brain.哺乳动物大脑中的腐胺分解代谢
Biochem J. 1974 Oct;144(1):29-35. doi: 10.1042/bj1440029.
2
4-aminobutyrate in mammalian putrescine catabolism.哺乳动物腐胺分解代谢中的4-氨基丁酸
Biochem J. 1975 Nov;152(2):201-10. doi: 10.1042/bj1520201.
3
On the role of GABA in vertebrate polyamine metabolism.γ-氨基丁酸在脊椎动物多胺代谢中的作用
Physiol Chem Phys. 1980;12(5):411-29.
4
Catabolism of polyamines.多胺的分解代谢
Amino Acids. 2004 Jun;26(3):217-33. doi: 10.1007/s00726-004-0070-z. Epub 2004 Apr 20.
5
Oxidative deamination of 14C putrescine in mouse tissues in vivo.
Arch Immunol Ther Exp (Warsz). 1980;28(6):907-10.
6
Formation of GABOB from 2-hydroxyputrescine and its anticonvulsant effect.由2-羟基腐胺生成γ-氨基β-羟基丁酸及其抗惊厥作用。
Pharmacol Biochem Behav. 1991 Oct;40(2):359-66. doi: 10.1016/0091-3057(91)90567-l.
7
Involvement of diamine oxidase in catabolism of 14C-putrescine in mice in vivo with special reference to the formation of gamma-aminobutyric acid.二胺氧化酶在小鼠体内14C-腐胺分解代谢中的作用，特别涉及γ-氨基丁酸的形成。
Agents Actions. 1981 Dec;11(6-7):679-84. doi: 10.1007/BF01978789.
8
Formation of GABA via oxidative deamination of putrescine in ovaries of immature rats after gonadotrophin stimulation.促性腺激素刺激后未成熟大鼠卵巢中通过腐胺氧化脱氨形成γ-氨基丁酸。
Agents Actions. 1980 Apr;10(1 Pt 2):106-7. doi: 10.1007/BF02024189.
9
In vitro metabolism of putrescine by diamine oxidase in tissues of the pregnant rat.怀孕大鼠组织中腐胺经二胺氧化酶的体外代谢
Agents Actions. 1980 Apr;10(1 Pt 2):104-6. doi: 10.1007/BF02024188.
10
On the formation of gamma-aminobutyric acid from putrescine in brain.
J Biochem. 1979 Jul;86(1):277-8.
引用本文的文献
1
encodes a mitochondrial putrescine transporter that promotes GABA synthesis.编码一种促进γ-氨基丁酸（GABA）合成的线粒体腐胺转运体。
bioRxiv. 2024 Jul 24:2024.07.23.604788. doi: 10.1101/2024.07.23.604788.
2
A metabolomics pipeline highlights microbial metabolism in bloodstream infections.代谢组学分析流程突出了血流感染中的微生物代谢。
Cell. 2024 Jul 25;187(15):4095-4112.e21. doi: 10.1016/j.cell.2024.05.035. Epub 2024 Jun 16.
3
Differences in neurochemical profiles of two gadid species under ocean warming and acidification.海洋变暖和酸化条件下两种鳕科鱼类神经化学特征的差异。
Front Zool. 2017 Oct 30;14:49. doi: 10.1186/s12983-017-0238-5. eCollection 2017.
4
Disinhibitory Action of Astrocytic GABA at the Perforant Path to Dentate Gyrus Granule Neuron Synapse Reverses to Inhibitory in Alzheimer's Disease Model.星形胶质细胞γ-氨基丁酸在穿通通路至齿状回颗粒神经元突触处的去抑制作用在阿尔茨海默病模型中转变为抑制作用。
Exp Neurobiol. 2015 Sep;24(3):211-8. doi: 10.5607/en.2015.24.3.211. Epub 2015 Sep 2.
5
Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition.由单胺氧化酶B合成的胶质细胞γ-氨基丁酸介导紧张性抑制。
J Physiol. 2014 Nov 15;592(22):4951-68. doi: 10.1113/jphysiol.2014.278754. Epub 2014 Sep 19.
6
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease.活性星形胶质细胞中的 GABA 会损害阿尔茨海默病小鼠模型的记忆。
Nat Med. 2014 Aug;20(8):886-96. doi: 10.1038/nm.3639. Epub 2014 Jun 29.
7
Association of putrescine, spermidine, spermine, and GABA with structural elements of brain cells.腐胺、亚精胺、精胺和 GABA 与脑细胞结构元素的关系。
Neurochem Res. 1976 Oct;1(5):469-99. doi: 10.1007/BF00964210.
8
NAD(+)-dependent formation ofγ-aminobutyrate (GABA) from glutamate.烟酰胺腺嘌呤二核苷酸（NAD(+))依赖型谷氨酸到γ-氨基丁酸（GABA）的转化。
Neurochem Res. 1976 Feb;1(1):113-31. doi: 10.1007/BF00965636.
9
A neuroprotective role for polyamines in a Xenopus tadpole model of epilepsy.多胺在爪蟾胚胎癫痫模型中具有神经保护作用。
Nat Neurosci. 2011 Apr;14(4):505-12. doi: 10.1038/nn.2777. Epub 2011 Mar 6.
10
Biosynthesis, degradation and pharmacological importance of the fatty acid amides.脂肪酸酰胺的生物合成、降解及药理重要性
Drug Discov Today. 2008 Jul;13(13-14):558-68. doi: 10.1016/j.drudis.2008.02.006. Epub 2008 Apr 3.
本文引用的文献
1
An investigation of the intracellular fluid of calf embryo muscle.对小牛胚胎肌肉细胞内液的一项研究。
Biochem J. 1949;45(1):99-105. doi: 10.1042/bj0450099.
2
3
SPERMIDINE, SPERMINE, AND RELATED AMINES.亚精胺、精胺及相关胺类
Pharmacol Rev. 1964 Sep;16:245-300.
4
5
Diamine oxidase in the brain of vertebrates.脊椎动物大脑中的二胺氧化酶。
J Neurochem. 1963 Mar;10:183-6. doi: 10.1111/j.1471-4159.1963.tb09481.x.
6
The metabolism of gamma-aminobutyric acid-4-C14 by intact rats.
J Biol Chem. 1959 Feb;234(2):347-9.
7
[Determination of spermin, spermidine, and other biogenic amines after separation by paper electrophoresis, and their quantity in animal organs].[纸电泳分离后精胺、亚精胺及其他生物胺的测定及其在动物器官中的含量]
Hoppe Seylers Z Physiol Chem. 1957;308(2-4):108-15.
8
Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse.清醒小鼠脑内注射药物所产生的药理效应。
Br J Pharmacol Chemother. 1957 Mar;12(1):12-5. doi: 10.1111/j.1476-5381.1957.tb01354.x.
9
Studies on the free amino acids and related compounds in the tissues of the cat.猫组织中游离氨基酸及相关化合物的研究。
J Biol Chem. 1954 Dec;211(2):927-39.
10
Diamine oxidase and cadaverine metabolism.二胺氧化酶与尸胺代谢。
J Biol Chem. 1954 Jan;206(1):461-4.
Zotero 插件