（+）-异去甲伪麻黄碱对离体大鼠子宫中催产素和前列腺素诱发反应的增强作用：其特异性和选择性。

Potentiation of oxytocin and prostaglandins-evoked responses by (+) INPEA on isolated rat uterus: its specificity and selectivity.

作者信息

Rao V S, Sharma P L

出版信息

Jpn J Pharmacol. 1974 Dec;24(6):893-901. doi: 10.1254/jjp.24.893.

DOI:10.1254/jjp.24.893

Abstract

The effect of (+) IPNEA on various stimulant drugs was examined on isolated rat uterus. Addition of (+) IPNEA (1 times 10- minus 5 g/ml) to the organ bath, produced marked potentiation in the contractile responses of oxytocin and prostaglandins. Potentiation was less significant to 5-HT, vasopressin, angiotensin and bradykinin. (+) INPEA did not potentiate the responses of oxytocin on isolated rat mammary strip and the responses of prostaglandins on rat stomach (fundus) strip, guinea-pig tracheal chain and guinea-pig ileum. The significance of these findings has been discussed.

摘要

在离体大鼠子宫上研究了（+）异戊烯腺嘌呤对各种兴奋性药物的作用。向器官浴槽中加入（+）异戊烯腺嘌呤（1×10⁻⁵ g/ml）后，催产素和前列腺素的收缩反应出现明显增强。对5-羟色胺、血管加压素、血管紧张素和缓激肽的增强作用较小。（+）异戊烯腺嘌呤对离体大鼠乳腺条上催产素的反应以及前列腺素对大鼠胃（胃底）条、豚鼠气管链和豚鼠回肠的反应均无增强作用。已对这些发现的意义进行了讨论。

相似文献

1

Potentiation of oxytocin and prostaglandins-evoked responses by (+) INPEA on isolated rat uterus: its specificity and selectivity.（+）-异去甲伪麻黄碱对离体大鼠子宫中催产素和前列腺素诱发反应的增强作用：其特异性和选择性。

Jpn J Pharmacol. 1974 Dec;24(6):893-901. doi: 10.1254/jjp.24.893.

2

Effect of intraperitoneal administration of (+)-INPEA on oxytocin and prostaglandin evoked responses of the isolated rat uterus.腹腔注射(+)-异去甲伪麻黄碱对催产素和前列腺素诱发的离体大鼠子宫反应的影响。

Br J Pharmacol. 1973 Jun;48(2):344P-345P.

3

Potentiating effect of d-INPEA on prostaglandin (PGF 2 and PGE 2 )-evoked contractions of the isolated rat uterus.d -异去甲伪麻黄碱对前列腺素（PGF₂和PGE₂）诱发的离体大鼠子宫收缩的增强作用。

Eur J Pharmacol. 1972 Dec;20(3):363-5. doi: 10.1016/0014-2999(72)90198-7.

4

Some pharmacological properties of a synthetic oxytocin analogue [1-N-carbamoyl-hemicystine-2-O-methyltyrosine]-oxytocin (carbamoyl-methyloxytocin), an antagonist to the neurohypophysial hormones.一种合成的催产素类似物[1-N-氨基甲酰基-半胱氨酸-2-O-甲基酪氨酸]-催产素（氨基甲酰甲基催产素）的一些药理学特性，它是神经垂体激素的拮抗剂。

Br J Pharmacol. 1970 Oct;40(2):342-60. doi: 10.1111/j.1476-5381.1970.tb09927.x.

5

The action of bradykinin and oxytocin on the isolated whole uterus and myometrium of the rat in oestrus.缓激肽和催产素对处于发情期的大鼠离体全子宫和子宫肌层的作用。

Br J Pharmacol. 1978 Sep;64(1):21-8. doi: 10.1111/j.1476-5381.1978.tb08636.x.

6

The detection and estimation of bradykinin in the circulating blood.循环血液中缓激肽的检测与测定。

Br J Pharmacol Chemother. 1967 Mar;29(3):367-77. doi: 10.1111/j.1476-5381.1967.tb01968.x.

7

[Reactivity of isolated rat myometrium to oxytocin, bradykinin and serotonin in the presence of prostaglandin F-2 alpha].[在前列腺素F-2α存在的情况下，离体大鼠子宫肌层对催产素、缓激肽和5-羟色胺的反应性]

Ginekol Pol. 1976 Mar;47(3):273-8.

8

Bioassay of oxytocin on the superfused mammary gland of the mouse, using an automatic apparatus.使用自动装置对小鼠乳腺灌流液进行催产素生物测定。

Br J Pharmacol. 1974 Mar;50(3):409-17.

9

Relationship between the uterotonic action of oxytocin and prostaglandins: oxytocin action and release of PG-activity in isolated nonpregnant and pregnant rat uteri.催产素与前列腺素子宫收缩作用之间的关系：催产素作用及非妊娠和妊娠大鼠离体子宫中前列腺素活性的释放

Biol Reprod. 1977 Nov;17(4):541-8. doi: 10.1095/biolreprod17.4.541.

10

[Potentiation of the effects of oxytocin and vasopressin by the magnesium ion on the smooth muscle of isolated rat uterus].[镁离子对离体大鼠子宫平滑肌催产素和加压素作用的增强]

Nihon Yakurigaku Zasshi. 1966 Nov 20;62(6):398-403.

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