Zola H
Clin Exp Immunol. 1974 Mar;16(3):469-79.
Immunization of mice with allogeneic tumour antigen in Freund's complete adjuvant (FCA) facilitates the growth of subsequent allografts of RI and BP8 tumours in C57/B1 mice. FCA by itself is less effective. In this particular experimental model, antigen given without FCA is not effective. The extent of facilitation depends on the tumour–host combination, on the physical form of the antigen, and on the time interval between pretreatment and tumour allograft. The immunosuppressive effect of FCA appears to be mediated through a direct effect on lymphocytes, largely independent of blocking factors or macrophage effects.
用弗氏完全佐剂（FCA）中的同种异体肿瘤抗原免疫小鼠，可促进RI和BP8肿瘤随后在C57/B1小鼠中的同种异体移植瘤生长。单独使用FCA效果较差。在这个特定的实验模型中，不使用FCA给予抗原无效。促进程度取决于肿瘤-宿主组合、抗原的物理形式以及预处理与肿瘤同种异体移植之间的时间间隔。FCA的免疫抑制作用似乎是通过对淋巴细胞的直接作用介导的，很大程度上独立于封闭因子或巨噬细胞的作用。
