Nathanson D, Gettleman L, Schnitman P, Shklar G
J Biomed Mater Res. 1978 Jan;12(1):13-33. doi: 10.1002/jbm.820120103.
Poly(methyl methacrylate) as used in polymer replica tooth implants was fabricated into 6 X 6 mm cylindrical specimens and cured in either an air oven, pressure pot, autoclave, or microwave oven. Polymer porosity was achieved by means of either 1) intrinsic foaming agents, or 2) compacting different sizes of large beads with a minimum of monomer, with dense PMMA used as a control. Specimens were then implanted in the long bones of baboons. Histology of thin-sectioned and ground specimens from the sacrificed animals revealed complete tissue ingrowth into implanted material made of medium and large PMMA beads, very superficial ingrowth into material containing foaming agents and anorganic bone chips, and no ingrowth into dense PMMA implants. None of the implants were rejected or caused chronic inflammation. The effect on histologic response of the different curing methods could not be distinguished.
用于聚合物复制牙齿植入物的聚甲基丙烯酸甲酯被制成6×6毫米的圆柱形标本，并在空气烘箱、压力罐、高压灭菌器或微波炉中固化。聚合物孔隙率可通过以下两种方式实现：1）使用固有发泡剂；2）用最少的单体压实不同尺寸的大珠子，以致密聚甲基丙烯酸甲酯作为对照。然后将标本植入狒狒的长骨中。对处死动物的薄切片和磨片标本进行组织学检查发现，组织完全长入由中、大尺寸聚甲基丙烯酸甲酯珠子制成的植入材料中，非常浅表地长入含有发泡剂和无机骨屑的材料中，而未长入致密聚甲基丙烯酸甲酯植入物中。所有植入物均未被排斥或引起慢性炎症。不同固化方法对组织学反应的影响无法区分。
