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兔体内存在体液胸腺因子的证据。

Evidence for a humoral thymic factor in rabbits.

作者信息

Trench C A, Watson J W, Walker F C, Gardner P S, Green C A

出版信息

Immunology. 1966 Feb;10(2):187-91.

PMID:4160442
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423644/
Abstract

Rabbits thymectomized between 12 and 36 hours after birth subsequently show reduced levels of circulating lymphocytes together with a lowered immunological response to human γ-globulin. These effects of thymectomy can, to a large extent, be prevented by means of intraperitoneal auto-transplants of thymus in a Millipore diffusion chamber. It appears possible that the epithelial-reticular cells of the transplant persist in the diffusion chamber and elaborate a humoral factor, or factors, which take part in the maturation of antibody-producing cells.

摘要

出生后12至36小时进行胸腺切除的兔子,其循环淋巴细胞水平随后会降低,同时对人γ球蛋白的免疫反应也会减弱。胸腺切除的这些影响在很大程度上可以通过在微孔扩散室中进行胸腺腹腔自体移植来预防。移植的上皮网状细胞似乎有可能在扩散室中持续存在,并产生一种或多种体液因子,这些因子参与产生抗体细胞的成熟过程。

相似文献

1
Evidence for a humoral thymic factor in rabbits.兔体内存在体液胸腺因子的证据。
Immunology. 1966 Feb;10(2):187-91.
2
[Role of the bone marrow-thymus system in antibody formation].[骨髓 - 胸腺系统在抗体形成中的作用]
Saishin Igaku. 1969 Jul;24(7):1426-35.
3
Thymus dependency of rosette-forming cells: evidence for a circulating thymic hormone.玫瑰花结形成细胞的胸腺依赖性:循环胸腺激素的证据。
Transplant Proc. 1972 Sep;4(3):345-50.
4
The adjuvant action of endotoxin in thymectomized mice.内毒素在胸腺切除小鼠中的佐剂作用。
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5
The mammalian homologue of the avian bursa of Fabricius. II. Extirpation, lethal x-irradiation, and reconstitution in rabbits. Effects on humoral immune responses, immunoglobulins, and lymphoid tissues.禽类法氏囊的哺乳动物同源物。II. 家兔的切除、致死性X射线照射及重建。对体液免疫反应、免疫球蛋白和淋巴组织的影响。
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[Effect of thymectomy on the blood picture and on antibody formation in the hamster].[胸腺切除对仓鼠血象及抗体形成的影响]
Pathol Microbiol (Basel). 1968;31(2):65-84.
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Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness.猪到狒狒模型中的异种胸腺肾脏和胸腺组织移植:I. 猪特异性T细胞无反应性的证据
Transplantation. 2003 May 27;75(10):1615-24. doi: 10.1097/01.TP.0000064335.50622.20.
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Effect of adult thymectomy on the recovery from immunological depression induced by anti-lymphocyte serum.成年胸腺切除对由抗淋巴细胞血清诱导的免疫抑制恢复的影响。
Surg Forum. 1965;16:209-11.
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[Functional aspects of thymectomy].[胸腺切除术的功能方面]
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[Reactivity disorder in thymectomized animals. Experimental studies of the problem of thymic death].[胸腺切除动物的反应性障碍。胸腺死亡问题的实验研究]
Minerva Medicoleg. 1968 Jan-Apr;88(1):50-4.

引用本文的文献

1
Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin).胸腺淋巴细胞生成因子(胸腺素)的制备、测定及部分纯化
Proc Natl Acad Sci U S A. 1966 Sep;56(3):1010-7. doi: 10.1073/pnas.56.3.1010.
2
Release of an immunologically active humoral factor from the isolated perfused thymus.从离体灌注胸腺中释放出一种具有免疫活性的体液因子。
Immunology. 1974 Jan;26(1):115-23.
3
Immunocompetence of spleen cells from neonatally thymectomized mice conferred in vitro by a syngeneic thymus extract.同基因胸腺提取物在体外赋予新生期切除胸腺小鼠脾细胞的免疫活性。

本文引用的文献

1
PARTIAL IMMUNOLOGICAL RESTORATION OF NEONATALLY THYMECTOMIZED RATS WITH THYMUS-CONTAINING DIFFUSION CHAMBERS.用含胸腺扩散小室对新生期切除胸腺的大鼠进行部分免疫恢复
Nature. 1965 Feb 13;205:716-7. doi: 10.1038/205716a0.
2
GROWTH AND MORPHOLOGY OF MOUSE LYMPHOMA CELLS IN DIFFUSION CHAMBERS.小鼠淋巴瘤细胞在扩散小室中的生长与形态
Proc Soc Exp Biol Med. 1964 Oct;117:45-50. doi: 10.3181/00379727-117-29492.
3
THE LYMPHOD TISSUES AND IMMUNE RESPONSES OF NEONATALLY THYMECTOMIZED MICE BEARING THYMUS TISSUE IN MILLIPORE DIFFUSION CHAMBERS.
J Exp Med. 1969 Oct 1;130(4):765-75. doi: 10.1084/jem.130.4.765.
新生期切除胸腺的小鼠在微孔扩散小室中携带胸腺组织时的淋巴组织和免疫反应
J Exp Med. 1964 Jan 1;119(1):177-94. doi: 10.1084/jem.119.1.177.
4
HUMORAL THYMIC FACTOR IN MICE: FURTHER EVIDENCE.小鼠体内的体液胸腺因子:进一步的证据。
Science. 1964 Mar 6;143(3610):1049-51. doi: 10.1126/science.143.3610.1049.
5
EVIDENCE FOR FUNCTION OF THYMIC TISSUE IN DIFFUSION CHAMBERS IMPLANTED IN NEONATALLY THYMECTOMIZED MICE. PRELIMINARY REPORT.植入新生期切除胸腺小鼠扩散盒中的胸腺组织功能的证据。初步报告。
J Natl Cancer Inst. 1963 Aug;31:199-217.
6
Antibody production by lymphocytes after in vitro contact with bacterial antigen and transfer to new-born rabbits.淋巴细胞在体外与细菌抗原接触后产生抗体并转移至新生兔体内。
Nature. 1958 Jan 11;181(4602):122. doi: 10.1038/181122a0.
7
A study of antigens active in the tannic acid hemagglutination test present in filtrates of culture of Mycobacterium tuberculosis.对结核分枝杆菌培养滤液中存在的、在鞣酸血凝试验中有活性的抗原的一项研究。
J Immunol. 1955 Jul;75(1):15-21.