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慢性精神分裂症患者中催眠药的使用:一些批判性评论。

The utilization of hypnotics in chronic schizophrenics: some critical remarks.

作者信息

Jus K, Jus A, Villeneuve A, Pires P, Fontaine P

出版信息

Biol Psychiatry. 1979 Dec;14(6):955-60.

PMID:41605
Abstract

Of 23 hospitalized chronic schizophrenic patients, all under neuroleptic medication, hypnotics taken previously for a long time could be totally withdrawn in 16 cases, and in 7 cases, the dosage was diminished by 30%, without any sleep impairment. The gradual reduction of hypnotics was accompanied by a shift of neuroleptic dosage to the evening and bedtime, with reduction of the morning and midday dose, without change of the total daily dose. A significant improvement in the psychic state was observed in 16 patients after withdrawal of the hypnotic; 7 patients showed a slight improvement after reduction of the hypnotic. Monthly or bimonthly reassessment of insomnia in the hospitalized population of chronic schizophrenics is indispensable to avoid the deleterious effects and abuse of hypnotic drugs.

摘要

在23名住院的慢性精神分裂症患者中,所有人都在服用抗精神病药物,之前长期服用的催眠药在16例患者中可以完全停用,7例患者的剂量减少了30%,且没有任何睡眠障碍。催眠药的逐渐减量伴随着抗精神病药物剂量向晚上和就寝时间转移,同时减少早上和中午的剂量,而每日总剂量不变。16例患者在停用催眠药后精神状态有显著改善;7例患者在减少催眠药剂量后有轻微改善。对住院慢性精神分裂症患者的失眠情况进行每月或每两个月一次的重新评估,对于避免催眠药物的有害影响和滥用是必不可少的。

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