Cormane R H, Ballieux R E, Kalsbeek G L, Hymans W
Clin Exp Immunol. 1966 Apr;1(2):207-12.
Immunofluorescence studies of skin lesions of discoid and systemic lupus erythematosus and also of the unaffected skin in systemic lupus erythematosus, revealed γ-globulin (IgG) apparently always present in the region of the dermo-epidermal junction; macroglobulin (IgM) and IgA were coincidentally bound to this region. In all the sections examined, L-chains type κ and λ proteins could, with the aid of the `double layer' method, be demonstrated in the dermo-epidermal junction. The impression was gained that the immunoglobulins IgM and IgA are mainly located in the adjacent sites of the dermo-epidermal junction, whereas IgG appears to be localized on the junction itself. The heterogeneity in respect to the occurrence of these classes of immunoglobulins is similar to that already known for antinuclear factors.
对盘状红斑狼疮和系统性红斑狼疮的皮肤损害以及系统性红斑狼疮未受累皮肤进行免疫荧光研究发现，γ球蛋白（IgG）显然始终存在于真皮表皮交界处；巨球蛋白（IgM）和IgA也同时结合于此区域。在所有检查的切片中，借助“双层”法可在真皮表皮交界处证实κ型和λ型轻链蛋白。由此得到的印象是，免疫球蛋白IgM和IgA主要位于真皮表皮交界处的相邻部位，而IgG似乎定位在交界处本身。这些类别的免疫球蛋白出现情况的异质性与抗核因子的已知情况相似。
