E1k，胆碱酯酶基因座1处的另一种定量变异体。
E1k, another quantitative variant at cholinesterase locus 1.
作者信息
Rubinstein H M, Dietz A A, Lubrano T
出版信息
J Med Genet. 1978 Feb;15(1):27-9. doi: 10.1136/jmg.15.1.27.
Abstract
Two families segregating for the atypical (E1a) allele at cholinesterase locus 1 are described. Unusual results for dibucaine inhibition led to the recognition of a new allele (E1k) also segregating in these families. The enzymatic and immunological data are consistent with the hypothesis that E1k causes reduction of 'usual' (E1u) molecules by about 33%. Whether the reduction of E1u caused by E1k is caused by retarded synthesis or accelerated degradation of serum cholinesterase remains to be determined.
摘要
描述了两个在胆碱酯酶基因座1上分离出非典型（E1a）等位基因的家族。丁卡因抑制试验的异常结果导致发现了一个也在这些家族中分离的新等位基因（E1k）。酶学和免疫学数据与E1k导致“正常”（E1u）分子减少约33%这一假说相符。E1k导致的E1u减少是由血清胆碱酯酶合成延迟还是降解加速引起的，仍有待确定。
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本文引用的文献
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A 'silent' pseudo-cholinesterase gene.一个“沉默”的拟胆碱酯酶基因。
Nature. 1962 Feb 10;193:561-2. doi: 10.1038/193561a0.
2
Increased plasma cholinesterase activity and succinylcholine resistance: a genetic variant.血浆胆碱酯酶活性增加与琥珀酰胆碱抵抗：一种基因变异
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A pseudocholinesterase variant (E Cynthiana) associated with elevated plasma enzyme activity.一种与血浆酶活性升高相关的假性胆碱酯酶变体（E辛辛那提型）。
Am J Hum Genet. 1969 Sep;21(5):486-98.
4
Silent cholinesterase gene: variations in the properties of serum enzyme in apparent homozygotes.沉默胆碱酯酶基因：明显纯合子血清酶特性的变异
J Clin Invest. 1970 Mar;49(3):479-86. doi: 10.1172/JCI106257.
5
6
New allele at cholinesterase locus 1.胆碱酯酶基因座1处的新等位基因。
J Med Genet. 1976 Feb;13(1):38-42. doi: 10.1136/jmg.13.1.38.
7
E1j, a quantitative variant at cholinesterase locus 1: immunological evidence.胆碱酯酶基因座1处的定量变异体E1j：免疫学证据
J Med Genet. 1976 Feb;13(1):43-5. doi: 10.1136/jmg.13.1.43.
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