Chan C C, Kalsner S
Can J Physiol Pharmacol. 1979 Oct;57(10):1192-5. doi: 10.1139/y79-179.
The effect of noradrenaline on the stimulation-induced efflux of tritium in cattle renal arteries preincubated with [3H]noradrenaline was determined. Preparations were stimulated transmurally, with 300 shocks over a range of frequencies (1--15 Hz) in the presence and absence of noradrenaline (3 X 10(-6) M). The agonist inhibited the efflux most at 1 Hz but the extent of the inhibition did not vary with frequency between 2, 5, and 15 Hz. It is concluded that a negative feedback system, modulating neurotransmitter release, and increasingly activated by endogenously released noradrenaline as the frequency of stimulation rises, cannot account for the pattern of efflux inhibition induced by exogenous noradrenaline.
测定了去甲肾上腺素对预先用[3H]去甲肾上腺素孵育的牛肾动脉中刺激诱导的氚流出的影响。在有和没有去甲肾上腺素（3×10^(-6) M）的情况下，通过跨壁刺激制备物，在一系列频率（1-15 Hz）下施加300次电击。该激动剂在1 Hz时对流出的抑制作用最大，但在2、5和15 Hz之间，抑制程度并不随频率变化。得出的结论是，一个调节神经递质释放的负反馈系统，随着刺激频率的升高，由内源性释放的去甲肾上腺素越来越多地激活，不能解释外源性去甲肾上腺素诱导的流出抑制模式。
