Grob P J, Isliker H C, Webb T
Immunology. 1967 Mar;12(3):275-83.
The specificities of antibodies involved in the agglutination of anti-D sensitized human red cells was studied using IgG and its fragments Fc and Fab as inhibitors. It was shown that commercial anti-globulin sera and specific sheep anti-IgG serum react with the antigenic groups common to IgG and Fc. Anti-Fab serum on the other hand agglutinated anti-D sensitized red cells by reacting with the antigenic groups common to IgG and Fab. This result is interpreted to mean that antibodies reacting with Fab have different specificities depending on whether IgG or Fab was used as antigen.
使用IgG及其片段Fc和Fab作为抑制剂，研究了参与抗-D致敏人红细胞凝集反应的抗体的特异性。结果表明，市售抗球蛋白血清和特异性羊抗IgG血清与IgG和Fc共有的抗原基团发生反应。另一方面，抗Fab血清通过与IgG和Fab共有的抗原基团发生反应，使抗-D致敏红细胞发生凝集。这一结果被解释为意味着与Fab反应的抗体根据使用IgG还是Fab作为抗原而具有不同的特异性。
