Koch H K, Häberle B, Meinhardt K, Enzan H, Lesch R
Virchows Arch B Cell Pathol. 1978 Jan 18;26(3):233-47. doi: 10.1007/BF02889551.
In rats hepatocellular cytoplasmic changes after daily repeated D-galactosamine (GalN) intoxication--i.e. subacute GalN intoxication--were studied by light and electron microscopy. The number of GalN injections--and thus the days of survival--was between one and 30. The rats were killed six hours after the last GalN injection. Less degenerative changes were found after repeated GalN injections. An increased formation of atypical dense bodies (ADB), a temporary pronounced lipid accumulation and changes of the rough and smooth endoplasmic reticulum were prominent features of subacute GalN intoxication. The implications with respect to a modified GalN action in subacute GalN intoxication are discussed with special reference to biochemical data obtained in the same experimental model (Schuchhardt et al., 1977).
通过光学显微镜和电子显微镜研究了大鼠每日重复注射D-半乳糖胺（GalN）即亚急性GalN中毒后的肝细胞质变化。GalN注射次数（即存活天数）在1至30次之间。在最后一次注射GalN后6小时处死大鼠。重复注射GalN后发现的退行性变化较少。非典型致密小体（ADB）形成增加、暂时性明显脂质蓄积以及粗面和滑面内质网的变化是亚急性GalN中毒的突出特征。结合在同一实验模型中获得的生化数据（舒查特等人，1977年），讨论了亚急性GalN中毒中GalN作用改变的相关影响。
