Welander C, Kjørstad K E, Kolstad P
Acta Obstet Gynecol Scand. 1978;57(2):161-4. doi: 10.3109/00016347809155896.
Two groups of patients with stage III ovarian carcinoma were selected for a randomized clinical trial. The first group consisted of 157 patients who had radical surgery at their first laparotomy, the second group consisted of 145 patients with inoperable disease. The aim of the trial was to compare the results of maximum external megavoltage irradiation, 5 000 rads, to a large abdominal field, with the results of a reduced dose, 3 000 rads, immediately followed by chemotherapy with an alkylating agent (Thio-tepa). In none of the groups, did maximum radiotherapy prove superior to the schedule of a reduced dose combined with chemotherapy. The less costly and time saving combined treatment was better tolerated than irradiation alone. Histological tumour type did not influence the prognosis in these advanced cases where spread was found outside the true pelvis.
两组III期卵巢癌患者被选入一项随机临床试验。第一组由157例在首次剖腹手术时接受根治性手术的患者组成，第二组由145例无法手术的患者组成。该试验的目的是比较对大的腹部区域进行5000拉德的最大体外兆伏放疗结果，与先进行3000拉德的减量放疗，随后立即用烷化剂（噻替派）进行化疗的结果。在任何一组中，最大剂量放疗都未被证明优于减量放疗联合化疗的方案。成本更低且节省时间的联合治疗比单独放疗耐受性更好。在这些已扩散至真骨盆以外的晚期病例中，组织学肿瘤类型不影响预后。
