Johnson A O, Effiong C E, Bamidele M A
Afr J Med Med Sci. 1977 Jun;6(2):75-9.
Lomotil liquid in a dose of 0.3 mg/kg/day has been compared with plain mist kaolin in controlling acute diarrhoea in young children aged 6 weeks to 2 years. Lomotil was found to stop the diarrhoea faster and significantly shorten the period of hospital admission than kaolin (P less than 0.05) in children whose diarrhoea was complicated by moderate dehydration. In those with mild dehydration lomotil had no advantage over kaolin. Children with severe dehydration treated with lomotil spent on the average much shorter period in hospital than those on kaolin, but the numbers were too small to allow for useful comparison. There was no adverse effect observed in any of subjects at the dose of lomotil used.
已将剂量为0.3毫克/千克/天的洛哌丁胺溶液与普通高岭土混悬液进行比较，以控制6周龄至2岁幼儿的急性腹泻。在腹泻并发中度脱水的儿童中，发现洛哌丁胺比高岭土能更快止泻，并显著缩短住院时间（P小于0.05）。在轻度脱水的儿童中，洛哌丁胺相对于高岭土并无优势。接受洛哌丁胺治疗的重度脱水儿童平均住院时间比接受高岭土治疗的儿童短得多，但样本数量太少，无法进行有效比较。在所使用的洛哌丁胺剂量下，未观察到任何受试者出现不良反应。
