Pauerstein C J, Eddy C A, Croxatto H D, Hess R, Siler-Khodr T M, Croxatto H B
Am J Obstet Gynecol. 1978 Apr 15;130(8):876-86. doi: 10.1016/0002-9378(78)90264-8.
These studies were undertaken to ascertain the interval between the estrogen and LH peaks and ovulation in women, rhesus monkeys, and baboons. Estrogen, progesterone, and LH were measured by RIA. Ovulation was documented by visual examination of the ovaries, histology of the corpora lutea, and recovery of ova. The data for human subjects was based on a group of 23 normal women scheduled for surgical sterilization. Blood was drawn daily between 8:30 and 10:30 P.M. beginning on day 10 of the cycle. Surgery was performed 1 to 5 days after the LH peak. The hormonal findings were correlated with the histology of the corpus luteum. The mean interval from the estrogen peak to ovulation was 34 hours, the interval from the estrogen peak to the LH peak was 24 hours, and that from the LH peak to ovulation was 9 hours. In 46 rhesus monkey cycles and in 53 baboon cycles diagnostic serial laparoscopic examinations were initiated following the estrogen peak and repeated every 24 hours until ovulation was confirmed. The mean interval between the estrogen peak and ovulation was 34 hours in the monkey and 41 hours in the baboon. The intervals from the estrogen peaks to the LH peaks were 12 hours in the monkey and 23 hours in the baboon. The intervals from LH peak to ovulation were 22 hours in the monkey and 18 hours in the baboon. Plasma progesterone levels were significantly increased prior to the LH peak in all three species.
开展这些研究是为了确定女性、恒河猴和狒狒体内雌激素峰与促黄体生成素（LH）峰之间的间隔以及排卵时间。采用放射免疫分析法（RIA）测定雌激素、孕酮和LH。通过肉眼检查卵巢、黄体组织学检查以及回收卵子来记录排卵情况。人类受试者的数据基于一组计划进行手术绝育的23名正常女性。从月经周期第10天开始，每天晚上8:30至10:30采集血液。在LH峰出现后1至5天进行手术。将激素检测结果与黄体组织学进行关联分析。从雌激素峰到排卵的平均间隔为34小时，从雌激素峰到LH峰的间隔为24小时，从LH峰到排卵的间隔为9小时。在46个恒河猴周期和53个狒狒周期中，在雌激素峰出现后开始进行系列诊断性腹腔镜检查，每24小时重复一次，直至确认排卵。恒河猴从雌激素峰到排卵的平均间隔为34小时，狒狒为41小时。恒河猴从雌激素峰到LH峰的间隔为12小时，狒狒为23小时。恒河猴从LH峰到排卵的间隔为22小时，狒狒为18小时。在所有三个物种中，LH峰出现前血浆孕酮水平均显著升高。
