Marchioro T L, Terasaki P I, Hutchison D E, Brettschneider L, Cerilli G J, Groth C G, Starzl T E
Transplantation. 1967 Jul;5(4):Suppl:831-6. doi: 10.1097/00007890-196707001-00008.
From March 1962 to April 1966, 118 patients were treated with renal transplantation, 3 with kidneys from identical twins, 9 with cadaveric homografts, and 106 with homografts from volunteer donors. Sixty-two of the patients are still alive after nine months to almost five years. The only completely satisfactory group was that of the identical twin recipients. The results after homotransplantation have not materially improved during this time despite the acquisition of increased experience, adjustments of timing and dosage of azathioprine and prednisone, and attempts to identify biologically suitable donors in advance of operation by tissue typing. It is suggested that an has been reached, beyond which further reduction in mortality and morbidity will depend primarily upon the effective application of new immunosuppressive techniques.
从1962年3月至1966年4月，118例患者接受了肾移植治疗，其中3例接受同卵双胞胎供肾，9例接受尸体同种异体肾移植，106例接受志愿供者的同种异体肾移植。62例患者在9个月至近5年后仍然存活。唯一完全令人满意的一组是同卵双胞胎受者。尽管在此期间积累了更多经验，调整了硫唑嘌呤和泼尼松的给药时间和剂量，并试图通过组织配型在手术前确定生物学上合适的供者，但同种移植的结果在此期间并没有实质性改善。有人认为，已经达到了一个极限，在此之后，死亡率和发病率的进一步降低将主要取决于新免疫抑制技术的有效应用。
