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1
The reactivity of subunits of IgM anti-B.IgM抗B亚单位的反应性
Immunology. 1967 Sep;13(3):235-40.
2
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Observations on the reactions between D-positive red cells and ( 125 I)IgM anti-D molecules and subunits.关于D阳性红细胞与（125I）IgM抗-D分子及亚基之间反应的观察
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Immunohaematological cross-allergenicity between penicillin and cephalothin in humans.青霉素与头孢噻吩在人体中的免疫血液学交叉变应性。
Clin Exp Immunol. 1968 May;3(4):343-57.
9
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引用本文的文献

1
Studies on human antibodies. 8. Properties and association constants of human antibodies to blood group A substance purified with insoluble specific adsorbents and fractionally fluted with mono- and oligosaccharide.人类抗体研究。8. 用不溶性特异性吸附剂纯化并用单糖和寡糖分级洗脱的抗血型A物质人类抗体的特性和结合常数。
J Exp Med. 1969 May 1;129(5):871-96. doi: 10.1084/jem.129.5.871.
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Quantitative studies with ( 125 I) IgM anti-Le.采用（125I）IgM抗-Le的定量研究。
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3
The functional activities of IgG and IgM anti-A and anti-B.IgG和IgM抗A及抗B的功能活性
Immunology. 1967 Sep;13(3):227-34.

本文引用的文献

1
CHARACTERIZATION OF A HUMAN MACROGLOBULIN. I. THE MOLECULAR WEIGHT OF ITS SUBUNIT.一种人巨球蛋白的特性。I. 其亚基的分子量
J Biol Chem. 1965 Aug;240:3325-33.
2
THE REACTION WITH RED CELLS OF 7S RABBIT ANTIBODY, ITS SUB-UNITS AND THEIR RECOMBINANTS.7S兔抗体及其亚基和重组体与红细胞的反应
Immunology. 1965 Apr;8(4):420-31.
3
STUDIES ON THE REACTION BETWEEN THE BLOOD-GROUP ANTIBODY ANTI-D AND ERYTHROCYTES.血型抗体抗-D与红细胞之间反应的研究
Biochem J. 1963 Sep;88(3):435-40. doi: 10.1042/bj0880435.
4
Fractionation of human blood group antibodies by gel filtration.通过凝胶过滤法分离人类血型抗体。
Scand J Clin Lab Invest. 1963;15 Suppl 69:130-8.
5
Surface alteration and the agglutinability of red cells.
Nature. 1957 Nov 16;180(4594):1049-50. doi: 10.1038/1801049a0.
6
Quantitative measurements concerning A and B antigen sites.关于A和B抗原位点的定量测量。
Vox Sang. 1967 May;12(5):321-8. doi: 10.1111/j.1423-0410.1967.tb03362.x.
7
Number of binding sites of rabbit macroglobulin antibody and its subunits.兔巨球蛋白抗体及其亚基的结合位点数
Immunochemistry. 1965 Dec;2(4):401-15. doi: 10.1016/0019-2791(65)90039-x.
8
The functional activities of IgG and IgM anti-A and anti-B.IgG和IgM抗A及抗B的功能活性
Immunology. 1967 Sep;13(3):227-34.

IgM抗B亚单位的反应性

The reactivity of subunits of IgM anti-B.

作者信息

Economidou J, Hughes-Jones N C, Gardner B

出版信息

Immunology. 1967 Sep;13(3):235-40.

PMID:4168017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1409348/
Abstract

The reactivity of native IgM anti-B and of the monomer subunits with B cells was investigated using I-labelled antibody. A proportion of the monomers produced by mercaptoethanol treatment retained antibody activity, but the value of the equilibrium constant of the subunits was reduced by a factor of 36–170 compared to that of the native IgM molecule. It is concluded that native IgM anti-B is attached to red cells by at least two combining sites and evidence is given which indicates that IgM anti-A behaves similarly.

摘要

使用碘标记抗体研究了天然 IgM 抗 B 及单体亚基与 B 细胞的反应性。巯基乙醇处理产生的一部分单体保留了抗体活性，但与天然 IgM 分子相比，亚基的平衡常数降低了 36 - 170 倍。得出的结论是，天然 IgM 抗 B 通过至少两个结合位点附着于红细胞，并且有证据表明 IgM 抗 A 的行为类似。