IgM抗B亚单位的反应性
The reactivity of subunits of IgM anti-B.
作者信息
Economidou J, Hughes-Jones N C, Gardner B
出版信息
Immunology. 1967 Sep;13(3):235-40.
Abstract
The reactivity of native IgM anti-B and of the monomer subunits with B cells was investigated using I-labelled antibody. A proportion of the monomers produced by mercaptoethanol treatment retained antibody activity, but the value of the equilibrium constant of the subunits was reduced by a factor of 36–170 compared to that of the native IgM molecule. It is concluded that native IgM anti-B is attached to red cells by at least two combining sites and evidence is given which indicates that IgM anti-A behaves similarly.
摘要
使用碘标记抗体研究了天然 IgM 抗 B 及单体亚基与 B 细胞的反应性。巯基乙醇处理产生的一部分单体保留了抗体活性，但与天然 IgM 分子相比，亚基的平衡常数降低了 36 - 170 倍。得出的结论是，天然 IgM 抗 B 通过至少两个结合位点附着于红细胞，并且有证据表明 IgM 抗 A 的行为类似。
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