Goldman J M, Hobbs J R
Immunology. 1967 Oct;13(4):421-31.
Immunoglobulins have been measured in fifty patients with Hodgkin's disease. Levels of γG were slightly raised as compared with a control population, but γA tended to be low and γM was generally at or below our lower limit of normal. These findings are discussed in relation to the duration of the disease, its clinical staging, and the possible effects of radiotherapy and chemotherapy. It is suggested that the reduced γM levels are due to decreased synthesis in the reticulo-endothelial system rather than to increased catabolism. Reference is made to the depression in delayed-type hypersensitivity found early in Hodgkin's disease and this and reduction in γM levels may both reflect the same derangement in lymphoid cells. The detection of α-globulin in the sera of 62 per cent of the patients is referred to and its association with other neoplastic reticuloses is emphasized.
已对50例霍奇金病患者的免疫球蛋白进行了检测。与对照组相比，γG水平略有升高，但γA往往较低，γM通常处于或低于我们的正常下限。结合疾病持续时间、临床分期以及放疗和化疗的可能影响对这些发现进行了讨论。有人提出，γM水平降低是由于网状内皮系统合成减少，而非分解代谢增加。文中提到了在霍奇金病早期发现的迟发型超敏反应抑制，γM水平降低和迟发型超敏反应抑制可能都反映了淋巴细胞的相同紊乱。文中提到在62%的患者血清中检测到α球蛋白，并强调了其与其他肿瘤性网状细胞增多症的关联。
