给哺乳期母鼠注射促甲状腺素释放激素（TRH）后，乳鼠血清促甲状腺激素（TSH）升高。

Increase of serum thyrotropin (TSH) os suckling rats after thyroliberin (TRH) injection to lactating mothers.

作者信息

Strbák V, Macho L

出版信息

Biol Neonate. 1977;32(5-6):331-5. doi: 10.1159/000241037.

Abstract

Injection of 50 microgram TRH to lactating rats 15 days after parturition was followed 4 h after treatment by an increase of serum TSH and a decrease of absolute and relative pituitary TSH content in suckling pups when compared to sucklings of saline-treated mothers. The weight of the pituitary and thyroid also decreased. Results indicate that TRH administered to lactating rats induces release of TSH from the pituitary of suckling pups. An increase of the variability of serum TSH and a decrease of pituitary TSH content at noon in pups of saline-treated mothers suggest the presence of diurnal variation of TSH secretion in 15-day-old rats.

摘要

在分娩后15天给哺乳大鼠注射50微克促甲状腺激素释放激素（TRH），与注射生理盐水的母鼠所哺育的幼鼠相比，处理后4小时，哺乳幼鼠血清促甲状腺激素（TSH）增加，垂体中TSH的绝对含量和相对含量降低。垂体和甲状腺的重量也减轻。结果表明，给哺乳大鼠注射TRH可诱导哺乳幼鼠垂体释放TSH。注射生理盐水的母鼠所哺育的幼鼠中午时血清TSH变异性增加，垂体TSH含量降低，这表明15日龄大鼠存在TSH分泌的昼夜变化。