Fevery J, De Wolf-Peeters C, De Vos R, Desmet V, Heirwegh K P
Biol Neonate. 1977;32(5-6):336-42. doi: 10.1159/000241038.
Bilirubin UDP-glucuronyltransferase and UDP-xylosyltransferase activity could already be demonstrated in rat liver from day 19 of fetal life onwards (4 days before birth). Bilirubin-glucuronide was present in hepatocytes of 21-day-old fetal liver strongly suggesting that the enzyme detected in vitro was really active in vivo. This further supports the theory that secretion from the cell is also immature. The known deficiency of UDP-glucose dehydrogenase in fetal and neonatal rat liver could lead to decreased intracellular concentrations of UDP-glucuronic acid and possibly to increased concentrations of UDP-glucose. However, no glucosides were present in the fetal hepatocytes.
从胎儿期第19天（出生前4天）起，即可在大鼠肝脏中检测到胆红素UDP - 葡萄糖醛酸基转移酶和UDP - 木糖基转移酶的活性。胆红素葡萄糖醛酸酯存在于21日龄胎儿肝脏的肝细胞中，这有力地表明体外检测到的酶在体内确实具有活性。这进一步支持了细胞分泌也不成熟的理论。已知胎儿和新生大鼠肝脏中UDP - 葡萄糖脱氢酶缺乏，这可能导致细胞内UDP - 葡萄糖醛酸浓度降低，并可能使UDP - 葡萄糖浓度升高。然而，胎儿肝细胞中不存在糖苷。
