肥胖与甲状腺功能。3. 肥胖女性甲状腺功能的一些指标与横纹肌能量代谢之间的关系。

Obesity and thyroid function. 3. Relationship between some indicators of thyroid function and the energy metabolism of striated muscle in obese women.

Vondra K, Rath R, Bass A, Strasek J, Vitek V

Endokrinologie. 1978 Feb;71(1):89-96.

Abstract

In a group of 23 obese women the relations between some indicators of thyroid function (thyroxine-binding globuline--T4BG, triiodothyronine-binding globuline--T3BG, Achilles tendon reflex--ART) on the one hand and activities of enzymes of the energy metabolism (hexokinase--HK, triose phosphate dehydrogenase--TPDH, lactate dehydrogenase--LDH, glycerol-3-phosphate dehydrogenase--GPDH, citrate synthease--CS, malate dehydrogenase--MDH, hydroxyacyl--COA dehydrogenase) in the quadriceps femoris muscle on the other hand were investigated. 2. Correlations were found between T4BG and TPDH, LDH and GPDH activities, between T3BG and TPDH and GPDH activities and between the value of the Achilles tendon reflex and TPDH activity. Functionally these enzymes activities are associated with glycolysis and hydrogen transport from cytoplasmatic NADH2. No correlations were found between enzymes of the aerobic metabolism incl. enzymes of fatty acid oxidation and indicators of thyroid function. 3. The results indicate a relationship between thyroid function and enzymes involved in glycolysis and hydrogen transport from cytoplasmatic NADH2. They do not suggest, however, the unequivocal conclusion that in obese women with reduced thyroid function there is a generally reduced energy supplying metabolism in skeletal muscle.

摘要

在一组23名肥胖女性中，研究了一方面甲状腺功能的某些指标（甲状腺素结合球蛋白——T4BG、三碘甲状腺原氨酸结合球蛋白——T3BG、跟腱反射——ART）与另一方面股四头肌中能量代谢酶（己糖激酶——HK、磷酸丙糖脱氢酶——TPDH、乳酸脱氢酶——LDH、甘油-3-磷酸脱氢酶——GPDH、柠檬酸合酶——CS、苹果酸脱氢酶——MDH、羟酰基辅酶A脱氢酶）活性之间的关系。2. 发现T4BG与TPDH、LDH和GPDH活性之间，T3BG与TPDH和GPDH活性之间，以及跟腱反射值与TPDH活性之间存在相关性。从功能上讲，这些酶的活性与糖酵解以及细胞质NADH2的氢转运有关。未发现有氧代谢酶（包括脂肪酸氧化酶）与甲状腺功能指标之间存在相关性。3. 结果表明甲状腺功能与参与糖酵解和细胞质NADH2氢转运的酶之间存在关系。然而，它们并未得出明确的结论，即甲状腺功能减退的肥胖女性骨骼肌中的能量供应代谢普遍降低。