人血清中的一类新型免疫球蛋白。

A new class of immunoglobulin in human serum.

作者信息

Johansson S G, Bennich H, Wide L

出版信息

Immunology. 1968 Feb;14(2):265-72.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1409295/

Abstract

A new class of normal immunoglobulin corresponding to a myeloma protein (myeloma-IgND), which fails to react with specific antisera to IgA, D, G and M (Johansson and Bennich, 1967) was detected in serum from sixty-two blood donors using a radio-immunosorbent technique (Wide and Porath, 1966). IgND in normal sera corresponds to myeloma-IgND in Ouchterlony gel diffusion analysis. Isolated IgND gave a reaction of identity with myeloma-IgND in Ouchterlony gel diffusion analysis. The concentrations of IgND in 93·5 per cent of the samples was within the range of 100–700 ng/ml. Normal levels of IgND were found in four samples apparently lacking IgA and/or IgD as determined by single radial immunodiffusion. Elevated levels of IgND were found in four samples one of which was from a subject with previously undiagnosed extrinsic asthma. It is concluded that myeloma-IgND represents a new class of human immunoglobulin.

摘要

采用放射免疫吸附技术（Wide和Porath，1966年），在62名献血者的血清中检测到了一类新的正常免疫球蛋白，它与骨髓瘤蛋白（骨髓瘤-IgND）相对应，且不能与针对IgA、D、G和M的特异性抗血清发生反应（Johansson和Bennich，1967年）。在双向琼脂扩散分析中，正常血清中的IgND与骨髓瘤-IgND相对应。在双向琼脂扩散分析中，分离出的IgND与骨髓瘤-IgND呈现同一性反应。93.5%的样本中IgND浓度在100 - 700 ng/ml范围内。通过单向放射免疫扩散法测定，在4个明显缺乏IgA和/或IgD的样本中发现了正常水平的IgND。在4个样本中发现IgND水平升高，其中1个样本来自一名先前未诊断出的外源性哮喘患者。结论是骨髓瘤-IgND代表了一类新的人类免疫球蛋白。