类风湿关节炎及其他关节炎血清和滑液抗核因子的临床免疫学研究
A clinico-immunological study of serum and synovial fluid antinuclear factors in rheumatoid arthritis and other arthritides.
作者信息
MacSween R N, Dalakos T G, Jasani M K, Boyle J A, Buchanan W W, Goudie R B
出版信息
Clin Exp Immunol. 1968 Jan;3(1):17-24.
Samples of serum and synovial fluid from 161 patients with various forms of arthritis have been examined for the presence of antinuclear factors (ANF). In rheumatoid arthritis 28% of patients had ANF in their serum, and in 22% ANF was found in the synovial fluid. In ten patients ANF was present in the serum alone. In three patients ANF was present in only the synovial fluid, and in one of these patients the finding of ANF in only one of two joints examined is adduced as evidence in favour of local production of ANF in synovial tissue. The ANF was present in the serum and synovial fluid as IgM in 75%, as IgG in 22% and as IgM/IgG in 3% of rheumatoid arthritis patients.
对161例患有各种类型关节炎患者的血清和滑液样本进行了抗核因子（ANF）检测。在类风湿性关节炎患者中，28%的患者血清中有ANF，22%的患者滑液中有ANF。10例患者仅血清中有ANF。3例患者仅滑液中有ANF，其中1例患者在检查的两个关节中仅一个关节发现ANF，这被作为滑膜组织中ANF局部产生的证据。在类风湿性关节炎患者中，75%的患者血清和滑液中的ANF为IgM，22%为IgG，3%为IgM/IgG。
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