5,6-二羟基色胺处理后大鼠蓝斑中酪氨酸羟化酶活性增加与血清素含量降低之间的相关性。
Correlation between the increase in tyrosine hydroxylase activity and the decrease in serotonin content in the rat locus coeruleus after 5,6-dihydroxytryptamine.
作者信息
McRae-Degueurce A, Pujol J F
出版信息
Eur J Pharmacol. 1979 Oct 26;59(1-2):131-5. doi: 10.1016/0014-2999(79)90035-9.
PMID:41727
Abstract
A correlation is demonstrated between the increase in tyrosine hydroxylase activity and the decrease in serotonin concentration in the rat locus coeruleus after various doses of 5,6-dihydroxytryptamine and gradual protection of serotonin neurons by pretreatment with two serotonin uptake inhibitors: fluoxetine or citalopram.
摘要
在给予大鼠不同剂量的5,6-二羟基色胺后，酪氨酸羟化酶活性增加与蓝斑中血清素浓度降低之间呈现出相关性，并且通过用两种血清素摄取抑制剂（氟西汀或西酞普兰）进行预处理，血清素神经元得到了逐步保护。
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