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Syntheses and pharmacological acitivity of compounds related to the antidepressant, 5-(2-dimethylaminoethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one(thiazesim). 3.

作者信息

Krapcho J, Turk C F, Piala J J

出版信息

J Med Chem. 1968 Mar;11(2):361-4. doi: 10.1021/jm00308a039.

DOI:10.1021/jm00308a039
PMID:4174063
Abstract
摘要

相似文献

1
Syntheses and pharmacological acitivity of compounds related to the antidepressant, 5-(2-dimethylaminoethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one(thiazesim). 3.与抗抑郁药5-(2-二甲基氨基乙基)-2,3-二氢-2-苯基-1,5-苯并硫氮杂䓬-4(5H)-酮(噻西sim)相关化合物的合成与药理活性。3.
J Med Chem. 1968 Mar;11(2):361-4. doi: 10.1021/jm00308a039.
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Phosphorus analogs of nitrogenous drugs. II. 10H-Dibenzo[1,4]thiaphosphorins as central nervous system depressants.
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Adamantyl analogs of the antidepressive, 5-(2-dimethylaminoethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one.
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Metabolism of thiazesim, 5-(2-dimethylaminoethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4 (5H)-one, in the rat in vivo and in vitro.噻氮䓬(5-(2-二甲基氨基乙基)-2,3-二氢-2-苯基-1,5-苯并硫氮杂䓬-4(5H)-酮)在大鼠体内及体外的代谢
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Pharmacological studies of a new series of bicyclic thymoleptics.
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Substituted 2,3-dihydro-1,5-benzothiazepin-4(5H)-one and related compounds. II. A new class of antidepressants.取代的2,3-二氢-1,5-苯并硫氮杂䓬-4(5H)-酮及相关化合物。II. 一类新型抗抑郁药。
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[Research on compounds with psychotropic activity. I. Synthesis of 5-phenylpyrrolo-(2,1-d)(1,5)-benzothiazepin-6,6-dioxide and 1,2,3,3a,4,5-hexahydro-5-phenylpyrrolo-(2,1-d)(1,5)-benzothiazepin-1,4-dione-6,6-dioxide, derivatives of a new heterocyclic system].[具有精神活性化合物的研究。I. 新型杂环体系衍生物5-苯基吡咯并-(2,1-d)(1,5)-苯并硫氮杂䓬-6,6-二氧化物和1,2,3,3a,4,5-六氢-5-苯基吡咯并-(2,1-d)(1,5)-苯并硫氮杂䓬-1,4-二酮-6,6-二氧化物的合成]
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Selective inhibitors of monoamine oxidase (MAO). 5. 1-Substituted phenoxathiin inhibitors containing no nitrogen that inhibit MAO A by binding it to a hydrophobic site.单胺氧化酶(MAO)的选择性抑制剂。5. 不含氮的1-取代吩恶噻因抑制剂,通过与疏水位点结合来抑制MAO A。
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Tetracyclic quinazolinone derivatives.四环喹唑啉酮衍生物
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Heterocycles [h]fused onto 4-oxoquinoline-3-carboxylic acid, part IV. Convenient synthesis of substituted hexahydro [1,4]thiazepino[2,3-h]quinoline-9-carboxylic acid and its tetrahydroquino[7,8-b]benzothiazepine homolog.稠合于4-氧代喹啉-3-羧酸上的杂环[h],第四部分。取代的六氢[1,4]噻氮杂卓并[2,3-h]喹啉-9-羧酸及其四氢喹啉并[7,8-b]苯并噻嗪同系物的简便合成。
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