评估英国丙种球蛋白预防传染性肝炎的效果。提交给公共卫生实验室服务主任的报告。
Assessment of British gammaglobulin in preventing infectious hepatitis. A report to the director of the Public Health Laboratory Service.
出版信息
Br Med J. 1968 Aug 24;3(5616):451-4.
A series of 87 controlled trials of the effectiveness of British gammaglobulin in preventing infectious hepatitis in schools and other institutions showed that gammaglobulin is very effective in these circumstances. No protection was given for the first two weeks after injection, probably because it was given during the incubation period of the hepatitis.The risks of developing hepatitis in contacts was found to vary greatly. In day schools there was usually little tendency for the disease to spread among the population, but the pupils in closest contact were at greater risk. In mental hospitals and children's homes, on the other hand, the tendency for the disease to spread was more pronounced.
一系列针对英国丙种球蛋白在学校及其他机构预防传染性肝炎有效性的87项对照试验表明，在这些情况下丙种球蛋白非常有效。注射后前两周没有提供保护，可能是因为在肝炎潜伏期给予了该药物。发现接触者感染肝炎的风险差异很大。在日间学校，疾病在人群中通常很少有传播趋势，但密切接触的学生风险更大。另一方面，在精神病院和儿童之家，疾病传播的趋势更为明显。
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