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血红蛋白尿患者肾上皮细胞中透明滴的形成。

Hyaline droplet formation in the renal epithelium of patients with haemoglobinuria.

作者信息

Bryant S J

出版信息

J Clin Pathol. 1967 Nov;20(6):854-6. doi: 10.1136/jcp.20.6.854.

DOI:10.1136/jcp.20.6.854
PMID:4177794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC473625/
Abstract

Renal hyaline droplet formation is described in two patients with haemoglobinuria. The droplets were shown to contain haemoglobin by a histochemical method. The findings are correlated with the results of recent experimental studies which have demonstrated that renal hyaline droplets are phagosomes containing absorbed protein and not products of cellular degeneration as was previously thought.

摘要

在两名血红蛋白尿患者中发现了肾透明滴形成。通过组织化学方法显示这些滴状物含有血红蛋白。这些发现与最近的实验研究结果相关，该研究表明肾透明滴是含有吸收蛋白的吞噬体，而不是像以前认为的那样是细胞变性的产物。

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本文引用的文献

1
The Permeability of the Renal Glomeruli of Several Mammalian Species to Labelled Proteins.几种哺乳动物物种的肾小球对标记蛋白质的通透性
Am J Pathol. 1947 Mar;23(2):255-67.
2
ABSORPTION AND DECOMPOSITION OF HOMOLOGOUS HEMOGLOBIN IN RENAL PROXIMAL TUBULAR CELLS.同源血红蛋白在肾近端小管细胞中的吸收与分解
Acta Pathol Microbiol Scand Suppl (1926). 1964;168:SUPPL 168:1+.
3
Hemoglobin absorption by the cells of the proximal convoluted tubule in mouse kidney.小鼠肾脏近端曲管细胞对血红蛋白的吸收
J Biophys Biochem Cytol. 1960 Dec;8(3):689-718. doi: 10.1083/jcb.8.3.689.
4
Changes in droplet fractions from rat kidney cells after intraperitoneal injection of egg white.腹腔注射蛋清后大鼠肾细胞中液滴组分的变化。
J Biophys Biochem Cytol. 1957 Nov 25;3(6):933-47. doi: 10.1083/jcb.3.6.933.
5
Cellular mechanisms of protein metabolism in the nephron. I. The structural aspects of proteinuria; tubular absorption, droplet formation, and the disposal of proteins.肾单位中蛋白质代谢的细胞机制。I. 蛋白尿的结构方面；肾小管吸收、液滴形成及蛋白质的处理。
J Exp Med. 1954 Jun 1;99(6):589-604. doi: 10.1084/jem.99.6.589.