Chouraqui J, Zeis A, Weniger J P
C R Acad Hebd Seances Acad Sci D. 1977 Dec 19;285(16):1475-8.
LH given to the Rat embryo at the time of hypophysectomy by decapitation (18 days of intrauterine life) will prevent the drop in androgen synthesis which normally ensues. This is regarded as definite proof that androgen synthesis is under pituitary control in the rat embryo at late gestational stages. On the other hand, the decrease in androgen synthesis following testosterone injection to the pregnant female points to the fact that there is a negative feedback of testosterone on pituitary LH secretion.
在子宫内发育18天时通过断头法切除垂体后给大鼠胚胎注射促黄体激素(LH),可防止雄激素合成量出现正常情况下会随之而来的下降。这被视为妊娠后期大鼠胚胎中雄激素合成受垂体控制的确凿证据。另一方面,给怀孕母鼠注射睾酮后雄激素合成减少,这表明睾酮对垂体促黄体激素的分泌存在负反馈作用。