螺[异苯并呋喃-1(3H),4'-哌啶]。3. 含与氮相连硫的化合物的利尿和降压特性。
Spiro[isobenzofuran-1(3H),4'-piperidines]. 3. Diuretic and antihypertensive properties of compounds containing a sulfur attached to nitrogen.
作者信息
Klioze S S, Novick W J
出版信息
J Med Chem. 1978 Apr;21(4):400-3. doi: 10.1021/jm00202a019.
PMID:418179
Abstract
The synthesis and antihypertensive and diuretic activity of several N-sulfur derivatives of 3-phenylspiro[isobenzofuran-1(3H),4'-piperidine] are reported. Benzenesulfenamide 3 possessed marked, species-specific diuretic and antihypertensive activity in rats.
摘要
报道了几种3-苯基螺[异苯并呋喃-1(3H),4'-哌啶]的N-硫衍生物的合成及其降压和利尿活性。苯亚磺酰胺3在大鼠中具有显著的、种属特异性的利尿和降压活性。
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