McLarty D G, Alexander W D, Harden R M, Clark D H
Br Med J. 1969 Jul 26;3(5664):203-5. doi: 10.1136/bmj.3.5664.203.
One hundred and thirty patients who relapsed after a full course of treatment with antithyroid drugs have been reviewed. Of 22 patients receiving a second course of antithyroid drugs, 17 (77%) relapsed. In contrast, only 2 out of 44 patients treated by surgery relapsed and seven became hypothyroid. Nevertheless, local complications, in particular parathyroid insufficiency, were especially common in this group. Eighty patients received radioiodine, 11 (14%) requiring more than three doses before finally being rendered euthyroid. Postradiation hypothyroidism developed in 39 (49%) patients.
对130例接受抗甲状腺药物全疗程治疗后复发的患者进行了回顾性研究。在接受第二疗程抗甲状腺药物治疗的22例患者中，17例（77%）复发。相比之下，接受手术治疗的44例患者中仅有2例复发，7例出现甲状腺功能减退。然而，该组局部并发症，尤其是甲状旁腺功能不全特别常见。80例患者接受了放射性碘治疗，其中11例（14%）在最终实现甲状腺功能正常之前需要超过三剂。39例（49%）患者出现放射性碘治疗后甲状腺功能减退。
