Jacobs S, Anderson G, Bailey S, Ottaviano J, McCarthy V
TIT J Life Sci. 1977;7(3-4):37-42.
Single unit activity from chronically implanted squirrel monkeys was analyzed to evaluate the effect of acupuncture stimulation on limbic and thalamic structures associated with pain. Extracellular recordings and computer-generated interspike interval histograms (ISIH) were obtained from n. parafasicularis and n. ventralis posteromedialis of the thalamus and the laternal septum, basal amygdala and anterior cigulate cortex. Thalamic activity remained unchanged while limibc units demonstrated statistically significant alterations in both cell firing rate and the ISIH in response to acupuncture stimulation. Although pain thresholds in response to tooth pulp stimulation were increased by morphine (37-51% +/- 2.1), acupuncture proved totally ineffective. This may be interpreted as a selective response to acupuncture in CNS structures primarily concerned with the affective component of pain.
分析慢性植入松鼠猴的单单位活动，以评估针刺刺激对与疼痛相关的边缘系统和丘脑结构的影响。从丘脑束旁核、丘脑腹后内侧核、外侧隔、基底杏仁核和前扣带回皮质获取细胞外记录和计算机生成的峰间期直方图（ISIH）。丘脑活动保持不变，而边缘系统单位在针刺刺激后，细胞放电率和ISIH均显示出具有统计学意义的变化。尽管吗啡可提高对牙髓刺激的疼痛阈值（37 - 51% +/- 2.1），但针刺证明完全无效。这可能被解释为中枢神经系统结构对针刺的选择性反应，主要涉及疼痛的情感成分。
