抗凝血酶3。注射凝血活酶后对死亡的保护作用。
Antithrombin 3. Protection against death after injection of thromboplastin.
作者信息
Mann L T, Jensenius J C, Simonsen M, Abildgaard U
出版信息
Science. 1969 Oct 24;166(3904):517-8. doi: 10.1126/science.166.3904.517.
PMID:4186074
Abstract
Intravenous injection of autologous lipoprotein (thromboplastin) or thrombin produced a lethal, hemorrhagic syndrome in chicken embryos. The embryos could be protected from this fatal result by injection of antithrombin III, an alpha(2)-globulin (molecular weight 60,000 to 80,000) purified from human, bovine, and guinea pig blood. Heparin also protected the embryos, but other inhibitors were less protective.
摘要
静脉注射自体脂蛋白（凝血活酶）或凝血酶会在鸡胚中引发致命的出血综合征。通过注射从人、牛和豚鼠血液中纯化得到的抗凝血酶III（一种α₂球蛋白，分子量为60,000至80,000），可使胚胎免受这种致命后果。肝素也能保护胚胎，但其他抑制剂的保护作用较弱。
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