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2-硝基咪唑衍生物苄硝唑的作用机制。

Mode of action of the 2-nitroimidazole derivative benznidazole.

作者信息

Polak A, Richle R

出版信息

Ann Trop Med Parasitol. 1978 Feb;72(1):45-54. doi: 10.1080/00034983.1978.11719278.

DOI:10.1080/00034983.1978.11719278
PMID:418744
Abstract

Using cultures of Trypanosoma cruzi cells in a liquid medium, the mode of action of the 2-nitroimidazole derivative benznidazole was examined. Benznidazole inhibits protein synthesis and RNA synthesis in T. cruzy. The DNA synthesis is only slightly decreased and no effect on the aerobic respiration of T. cruzi was observed.

摘要

利用克氏锥虫细胞在液体培养基中的培养物，研究了2-硝基咪唑衍生物苯硝唑的作用方式。苯硝唑抑制克氏锥虫中的蛋白质合成和RNA合成。DNA合成仅略有下降，且未观察到对克氏锥虫有氧呼吸的影响。

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