绵羊进食后循环系统的变化及肾素分泌
Circulatory changes and renin secretion in sheep in response to feeding.
作者信息
Blair-West J R, Brook A H
出版信息
J Physiol. 1969 Sep;204(1):15-30. doi: 10.1113/jphysiol.1969.sp008895.
Abstract
- The effect of feeding on the circulation, on renin release and on renal function has been examined in the sheep.2. There was a rapid reduction of plasma volume within 15 min of starting to eat dry feed.3. This was accompanied by an abrupt rise in systolic blood pressure and by a more gradual and prolonged elevation of heart rate.4. Within 30 min of feeding there occurred renal conservation of sodium and water which continued for at least 2-3 hr.5. Renin was released into the circulation of sheep that ate rapidly; slow feeders did not show this response.6. The rise in plasma renin concentration was inhibited by infusing a solution similar in composition to mixed saliva at a rate that prevented the change in plasma volume.7. It is concluded that the rapid transfer of sodium and water from the circulation to the rumen via the saliva during ingestion of dry feed is sufficient to activate the renin/angiotensin system.
摘要
已在绵羊身上研究了进食对循环系统、肾素释放及肾功能的影响。
开始进食干饲料后15分钟内，血浆量迅速减少。
这伴随着收缩压的突然升高以及心率更缓慢且持续时间更长的升高。
进食后30分钟内，肾脏开始保钠保水，这种情况持续至少2 - 3小时。
快速进食的绵羊肾素释放进入循环系统；进食慢的绵羊未出现这种反应。
通过以防止血浆量变化的速率输注成分与混合唾液相似的溶液，可抑制血浆肾素浓度的升高。
得出的结论是，在摄入干饲料期间，钠和水通过唾液从循环系统快速转移至瘤胃足以激活肾素/血管紧张素系统。
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