Davenport J W
Science. 1970 Feb 13;167(3920):1007-8. doi: 10.1126/science.167.3920.1007.
Rats reared on diets containing tricyanoaminopropene, the antithyroid compound that stimulates RNA synthesis, showed a deficit in performance on automated closed-field maze tests many weeks after discontinuation of the drug. The rats were also tested while still receiving the drug, and performance deficits were indicated in tests of Y-maze reversal and manual closed-field maze performance; rats treated with the drug and with thiouracil behaved in a highly similar fashion on several tasks. No evidence of facilitation by tricyanoaminopropene appeared in any of the eight learning situations used. Exposure to tricyanoaminopropene before and after birth, at doses sufficient to produce anatomical cretinism, apparently induces an enduring behavioral deficit which is similar to that of neonatal thyroidectomy-induced cretinism in rats and which parallels the mental retardation associated with human cretinism.
用含有抗甲状腺化合物三氰基氨基丙烯的饲料饲养的大鼠，这种化合物能刺激RNA合成，在停药许多周后，在自动封闭场迷宫测试中表现出行为缺陷。这些大鼠在仍接受药物治疗时也进行了测试，在Y迷宫反转和手动封闭场迷宫表现测试中显示出行为缺陷；用该药物和硫脲嘧啶治疗的大鼠在几项任务中的行为方式高度相似。在所使用的八种学习情境中，均未出现三氰基氨基丙烯促进作用的证据。出生前后接触足以导致解剖学上克汀病的剂量的三氰基氨基丙烯，显然会诱发一种持久的行为缺陷，这种缺陷类似于大鼠新生儿甲状腺切除诱发的克汀病，并且与人类克汀病相关的智力迟钝情况相似。
