Hogarth-Scott R S, Johansson S G, Bennich H
Clin Exp Immunol. 1969 Dec;5(6):619-25.
It was possible to detect in the sera of patients, for whom visceral larva migrans had been confirmed histologically, not only antibodies to the excretory–secretory antigens of by means of fluorescence techniques, but also specific homocytotropic antibody measured by passive cutaneous anaphylactic tests in baboons and monkeys. It was observed that these patients had ten to fifteen times the average normal level of IgE as determined by the radioimmunosorbent test. All cases authenticated histologically gave these results, which suggests that these sort of serological findings can make a contribution towards establishing a diagnosis of visceral larva migrans in man. A schematic representation is given which shows the immunological responses of the host which may result from different nematode allergens and antigens, and the immunopathological mechanisms likely to be involved.
通过荧光技术，不仅可以在经组织学确诊为内脏幼虫移行症的患者血清中检测到针对[某种寄生虫名称未给出]排泄分泌抗原的抗体，还能通过在狒狒和猴子身上进行的被动皮肤过敏试验检测到特异性亲细胞性抗体。据观察，通过放射免疫吸附试验测定，这些患者的IgE水平是正常平均水平的十到十五倍。所有经组织学证实的病例都得出了这些结果，这表明这类血清学检查结果有助于确诊人类内脏幼虫移行症。文中给出了一个示意图，展示了宿主可能因不同线虫过敏原和抗原产生的免疫反应，以及可能涉及的免疫病理机制。
