Granat M, Sharf M, Cooper A
Obstet Gynecol. 1979 Feb;53(2):157-61.
This study was designed to examine various risk factors in regard to their correlation with carbohydrate intolerance and in relation to birthweight and well-being of the newborn. Of the various alleged prediabetic stigmata among a selected group of 390 women, only marked maternal overweight, diabetes in previous pregnancy, family history of diabetes at the sibling level, and accompanying maternal morbidity were associated with increased risk for both gestational carbohydrate intolerance and for morbidity in the newborn. In women over 30 years of age a definite increase in the incidence of carbohydrate intolerance was noted among this high-risk population. Multiplicity of screening criteria presented a significantly (P less than 0.001) greater risk for the development of carbohydrate intolerance and was seen to be positively (P less than 0.001) with increased perinatal morbidity.
本研究旨在探讨各种风险因素与碳水化合物不耐受的相关性，以及与新生儿出生体重和健康状况的关系。在选定的390名女性群体中，各种所谓的糖尿病前期特征中，只有明显的孕妇超重、既往妊娠糖尿病、兄弟姐妹一级的糖尿病家族史以及伴随的孕妇发病与妊娠期碳水化合物不耐受和新生儿发病风险增加有关。在30岁以上的女性中，在这一高危人群中观察到碳水化合物不耐受的发生率有明显增加。筛查标准的多样性使发生碳水化合物不耐受的风险显著增加（P<0.001），并且与围产期发病率增加呈正相关（P<0.001）。
