Spearing G
Obstet Gynecol. 1979 Feb;53(2):171-4.
In a comparative trial, ethanol effectively arrested preterm labor for 48 hours for more in 32% of cases, a beta-adrenergic agent (salbutamol) in 60% of cases (not statistically significant), and a combination of ethanol and indomethacin in 70% of cases (statistically significant, P less than 0.5). Labor was delayed for 14 days or more in 36, 60, and 50%, respectively (not statistically significant). The numbers studied were small, and tests of statistical significance were of doubtful value. Salbutamol was more acceptable to patients and the staff than ethanol. The trial was suspended and eventually abandoned due to reports of prostaglandin synthetase inhibitors causing premature closure of the ductus arteriosus. In this series no problems were encountered with the use of indomethacin.
在一项对比试验中，乙醇在32%的病例中有效地抑制早产达48小时以上，β-肾上腺素能药物（沙丁胺醇）在60%的病例中有效（无统计学意义），乙醇与吲哚美辛联合使用在70%的病例中有效（有统计学意义，P小于0.5）。分别有36%、60%和50%的病例分娩延迟了14天或更长时间（无统计学意义）。研究的病例数较少，统计学显著性检验的价值存疑。患者和医护人员对沙丁胺醇的接受度高于乙醇。由于有报道称前列腺素合成酶抑制剂会导致动脉导管过早闭合，该试验被暂停并最终放弃。在本系列研究中，使用吲哚美辛未遇到任何问题。
