[Dynamics of cellular and humoral immunologic reactions following insulin administration to guinea pigs].

Prolonged daily insulin administration to guinea pigs induced humoral and cellular immunological reactions to insulin; the earliest phenomena were reactions of lymphocyte blast-cell transformation and delayed skin hypersensitivity. Inhibition of macrophage migration and immediate skin hypersensitivity, as well as circulating insulin antibodies appeared later. Following prolonged 3--6 month insulin administration the blast-cell transformation reaction to insulin becomes negative; as to other immunological reactions under study--they displayed sensitization to insulin.