Vel'bri S K
Probl Endokrinol (Mosk). 1979 Jan-Feb;25(1):36-9.
Prolonged daily insulin administration to guinea pigs induced humoral and cellular immunological reactions to insulin; the earliest phenomena were reactions of lymphocyte blast-cell transformation and delayed skin hypersensitivity. Inhibition of macrophage migration and immediate skin hypersensitivity, as well as circulating insulin antibodies appeared later. Following prolonged 3--6 month insulin administration the blast-cell transformation reaction to insulin becomes negative; as to other immunological reactions under study--they displayed sensitization to insulin.
每日对豚鼠长期注射胰岛素会引发对胰岛素的体液免疫和细胞免疫反应；最早出现的现象是淋巴细胞母细胞转化反应和迟发性皮肤超敏反应。巨噬细胞游走抑制和速发性皮肤超敏反应以及循环胰岛素抗体随后出现。在长期注射胰岛素3 - 6个月后，对胰岛素的母细胞转化反应变为阴性；至于所研究的其他免疫反应——它们表现出对胰岛素的致敏作用。
