Saletu B, Grünberger J
Pharmakopsychiatr Neuropsychopharmakol. 1979 Jan;12(1):45-58. doi: 10.1055/s-0028-1094593.
Quantitative EEG analyses in combination with certain statistical procedures may be utilized in order to classify psychotropic drugs and to determine their cerebral bioavailability. Psychometric tests including evaluation of attention, concentration, psychomotor activity, critical flicker frequency, reaction time, Archimedean spiral, mood and affectivity, may add valuable information about a drug's psychotropic and pharmacodynamic properties. As was seen in studies involving a new pyridodiazepine, short-term drug effects in the EEG of normals are predictive of EEG and clinical effects in patients. Pharmaco-EEG profiles of lopirazepam were found similar in normals and alcoholic patients with an anxiety syndrom as far as the type of changes was concerned, although some quantitative differences were observed. As previously described, quantitative EEG changes during treatment were correlated with clinical improvement or deterioration. Moreover, there is some evidence that single dose effects in the EEG of patients may eventually be utilized to predict therapeutic outcome with a certain drug. Finally, relationships between blood level, quantitative EEG and psychometric changes after administration of phentermine and oxazepam are described and discussed.
定量脑电图分析结合某些统计程序可用于对精神药物进行分类并确定其脑内生物利用度。心理测试，包括注意力、专注力、精神运动活动、临界闪烁频率、反应时间、阿基米德螺旋线、情绪和情感评估，可为药物的精神药理和药效学特性提供有价值的信息。正如在涉及一种新型吡啶二氮䓬的研究中所见，正常人脑电图中的短期药物效应可预测患者的脑电图和临床效应。就变化类型而言，在正常人和患有焦虑综合征的酒精性患者中发现氯吡西泮的药物脑电图特征相似，尽管观察到了一些定量差异。如前所述，治疗期间的定量脑电图变化与临床改善或恶化相关。此外，有证据表明患者脑电图中的单剂量效应最终可能用于预测某种药物的治疗结果。最后，描述并讨论了服用芬特明和奥沙西泮后血药浓度、定量脑电图和心理测量变化之间的关系。
