Br Med J. 1970 May 30;2(5708):497-500.
Studies were done on 5,447 pregnant women given immunoglobulin after exposure to rubella and on 652 adult women similarly at risk but not pregnant and therefore not given immunoglobulin. The amounts of immunoglobulin, of known antibody content ranged from 750 mg. to more than 1,500 mg.; in a few second doses were given. Preinoculation blood samples from both groups showed that about 15% were still susceptible. Second blood samples were obtained from many of the women and nasal and throat swabs from as many index cases as possible. In the development of rubella by susceptible women a major factor was an index case in the same household. Whether judged on the serological evidence alone, or as a result of exposure to a confirmed index case, immunoglobulin in the amounts given did not appear to affect the incidence of rubella by comparison with the uninoculated group. Suppression of clinical manifestations attributable to immunoglobulin was possible in a few instances, but this could also have been an example of natural variation.
对5447名接触风疹后接受免疫球蛋白治疗的孕妇以及652名同样有风险但未怀孕因而未接受免疫球蛋白治疗的成年女性进行了研究。已知抗体含量的免疫球蛋白剂量范围为750毫克至超过1500毫克；少数人接受了第二剂。两组接种前的血样显示，约15%的人仍易感。从许多女性身上采集了第二份血样，并从尽可能多的索引病例中采集了鼻拭子和咽拭子。在易感女性感染风疹的过程中，一个主要因素是同一家庭中的索引病例。无论是仅根据血清学证据判断，还是由于接触确诊的索引病例，与未接种组相比，所给剂量的免疫球蛋白似乎并未影响风疹的发病率。在少数情况下，免疫球蛋白可能抑制了临床表现，但这也可能是自然变异的一个例子。
